ArticleMolecular biology of the cell2007
Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed.
- Exploring serum and glucocorticoid-regulated kinase 1: A promising target for COVID-19 and atrial fibrillation treatment.Heart rhythm O2 · 2025Review
- Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain.Experimental neurology · 2024Review
- Cell autonomous and non-autonomous consequences of deviations in translation machinery on organism growth and the connecting signalling pathways.Open biology · 2022Review
- SGK1, autophagy and cancer: an overview.Molecular biology reports · 2022Review
- Article
- Serum and Glucocorticoid-Inducible Kinase 1 (SGK1) in NSCLC Therapy.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Glucocorticoid receptor signaling in astrocytes is required for aversive memory formation.Translational psychiatry · 2018Article
- The neuronal-specific SGK1.1 (SGK1_v2) kinase as a transcriptional modulator of BAG4, Brox, and PPP1CB genes expression.International journal of molecular sciences · 2015Article
- Article
- The mTOR pathway controls cell proliferation by regulating the FoxO3a transcription factor via SGK1 kinase.PloS one · 2014Article
- Article
- The neuronal serum- and glucocorticoid-regulated kinase 1.1 reduces neuronal excitability and protects against seizures through upregulation of the M-current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Ethanol regulation of serum glucocorticoid kinase 1 expression in DBA2/J mouse prefrontal cortex.PloS one · 2013Article
- Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.EMBO molecular medicine · 2013Article
- Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.PloS one · 2012Article
- Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1.The Journal of biological chemistry · 2011Article
- Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization.The Journal of biological chemistry · 2010Article
- Targeting SGK1 in diabetes.Expert opinion on therapeutic targets · 2009Review
- The physiological impact of the serum and glucocorticoid-inducible kinase SGK1.Current opinion in nephrology and hypertension · 2009Review
- Epithelial sodium channel regulated by differential composition of a signaling complex.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Serum- and glucocorticoid-induced kinase 1 is a ubiquitous kinase that regulates diverse processes such as ion transport and cell survival. We report that a single SGK1 mRNA produces isoforms with different N-termini owing to alternative translation initiation. The long isoforms, 49 and 47 kDa, are the most abundant, localize to the ER membrane, exhibit rapid turnover, their expression is decreased by ER stress, activate the epithelial sodium channel (ENaC) and translocate FoxO3a transcriptional factors from the nucleus to the cytoplasm. The short isoforms, 45 and 42 kDa, localize to the cytoplasm and nucleus, exhibit long half-life and phosphorylate glycogen synthase kinase-3beta. The data indicate that activation of Sgk1 in different cellular compartments is key to providing functional specificity to Sgk1 signaling pathways. We conclude that the distinct properties and functional specialization of Sgk1 given by the N-terminus confer versatility of function while maintaining the same core kinase domain.
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