ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Maturation of ribbon synapses in hair cells is driven by thyroid hormone.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 85 citations in OpenAlex.
- The Role of Thyroid Hormone Signaling in the Development and Pathophysiology of Hearing: From Molecular Mechanisms to Clinical Applications.International journal of molecular sciences · 2026Review
- Nuclear Translocation Triggered at the Onset of Hearing in Cochlear Inner Hair Cells of Rats and Mice.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Cochlear hair cell innervation is dependent on a modulatory function of Semaphorin-3A.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring.International archives of otorhinolaryngology · 2022Article
- Autophagy-Mediated Synaptic Refinement and Auditory Neural Pruning Contribute to Ribbon Synaptic Maturity in the Developing Cochlea.Frontiers in molecular neuroscience · 2022Article
- Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses.eLife · 2021Article
- Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor.BMC biology · 2021Article
- Macrophages Are Dispensable for Postnatal Pruning of the Cochlear Ribbon Synapses.Frontiers in cellular neuroscience · 2021Article
- The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development.The FEBS journal · 2021Article
- Congenital Hypothyroidism and the Deleterious Effects on Auditory Function and Language Skills: A Narrative Review.Frontiers in endocrinology · 2021Review
- Molecular Assembly and Structural Plasticity of Sensory Ribbon Synapses-A Presynaptic Perspective.International journal of molecular sciences · 2020Review
- Hair Cell Afferent Synapses: Function and Dysfunction.Cold Spring Harbor perspectives in medicine · 2019Review
- Semaphorin-5B Controls Spiral Ganglion Neuron Branch Refinement during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Current concepts in cochlear ribbon synapse formation.Synapse (New York, N.Y.) · 2019Review
- Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.eLife · 2018Article
- Gαi Proteins are Indispensable for Hearing.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018Article
- Spatial Gradients in the Size of Inner Hair Cell Ribbons Emerge Before the Onset of Hearing in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- RIM-Binding Protein 2 Promotes a Large Number of CaFrontiers in cellular neuroscience · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Ribbon synapses of inner hair cells (IHCs) undergo developmental maturation until after the onset of hearing. Here, we studied whether IHC synaptogenesis is regulated by thyroid hormone (TH). We performed perforated patch-clamp recordings of Ca2+ currents and exocytic membrane capacitance changes in IHCs of athyroid and TH-substituted Pax8-/- mice during postnatal development. Ca2+ currents remained elevated in athyroid IHCs at the end of the second postnatal week, when it had developmentally declined in wild-type and TH-rescued mutant IHCs. The efficiency of Ca2+ influx in triggering exocytosis of the readily releasable vesicle pool was reduced in athyroid IHCs. Ribbon synapses were formed despite the TH deficiency. However, different from wild type, in which synapse elimination takes place at approximately the onset of hearing, the number of ribbon synapses remained elevated in 2-week-old athyroid IHCs. Moreover, the ultrastructure of these synapses appeared immature. Using quantitative reverse transcription-PCR, we found a TH-dependent developmental upregulation of the mRNAs for the neuronal SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins, SNAP25 (synaptosomal-associated protein of 25 kDa) and synaptobrevin 1, in the organ of Corti. These molecular changes probably contribute to the improvement of exocytosis efficiency in mature IHCs. IHCs of 2-week-old athyroid Pax8-/- mice maintained the normally temporary efferent innervation. Moreover, they lacked large-conductance Ca2+-activated K+ channels and KCNQ4 channels. This together with the persistently increased Ca2+ influx permitted continued action potential generation. We conclude that TH regulates IHC differentiation and is essential for morphological and functional maturation of their ribbon synapses. We suggest that presynaptic dysfunction of IHCs is a mechanism in congenital hypothyroid deafness.
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