ArticleProceedings of the National Academy of Sciences of the United States of America2007
RNA interference screen to identify genes required for Drosophila embryonic nervous system development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
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- Decoding bee cleptoparasitism through comparative transcriptomics of Coelioxoides waltheriae and its host Tetrapedia diversipes.Scientific reports · 2024Article
- Application and prospects of high-throughput screening forWorld journal of stem cells · 2022Review
- Patched-Related Is Required for Proper Development of EmbryonicFrontiers in neuroscience · 2022Article
- Roles for Mitochondrial Complex I Subunits in Regulating Synaptic Transmission and Growth.Frontiers in neuroscience · 2022Article
- A Broad-Based Mosquito Yeast Interfering RNA Pesticide TargetingPathogens (Basel, Switzerland) · 2021Article
- IMP regulates Kuzbanian to control the timing of Notch signalling inDevelopment (Cambridge, England) · 2019Article
- An efficient and multiple target transgenic RNAi technique with low toxicity in Drosophila.Nature communications · 2018Article
- The Splicing FactorJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- RNAi-Mediated Reverse Genetic Screen IdentifiedG3 (Bethesda, Md.) · 2017Article
- Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis inDevelopment (Cambridge, England) · 2017Article
- PHYTOCHROME AND FLOWERING TIME1/MEDIATOR25 Regulates Lateral Root Formation via Auxin Signaling in Arabidopsis.Plant physiology · 2014Article
- Peroxisome deficient invertebrate and vertebrate animal models.Frontiers in physiology · 2013Review
- Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Ect2, an ortholog of Drosophila Pebble, regulates formation of growth cones in primary cortical neurons.Neurochemistry international · 2012Article
- Identification, expression and target gene analyses of Micrornas in Spodoptera litura.PloS one · 2012Article
- Codes and circuits.Cellular and molecular neurobiology · 2011Review
- Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma × glioma hybrid NG108-15 cells.Cellular and molecular neurobiology · 2011Article
- Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
RNA interference (RNAi) has been shown to be a powerful method to study the function of genes in vivo by silencing endogenous mRNA with double-stranded (ds) RNA. Previously, we performed in vivo RNAi screening and identified 43 Drosophila genes, including 18 novel genes required for the development of the embryonic nervous system. In the present study, 22 additional genes affecting embryonic nervous system development were found. Novel RNAi-induced phenotypes affecting nervous system development were found for 16 of the 22 genes. Seven of the genes have unknown functions. Other genes found encode transcription factors, a chromatin-remodeling protein, membrane receptors, signaling molecules, and proteins involved in cell adhesion, RNA binding, and ion transport. Human orthologs were identified for proteins encoded by 16 of the genes. The total number of dsRNAs that we have tested for an RNAi-induced phenotype affecting the embryonic nervous system, including our previous study, is 7,312, which corresponds to approximately 50% of the genes in the Drosophila genome.
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