ArticleJournal of neurophysiology2007
Voltage-dependent calcium channel CaV1.3 subunits regulate the light peak of the electroretinogram.
Article in Journal of neurophysiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- Review of the clinical electrooculogram - Part 1: Mechanism of the Light-Rise.Documenta ophthalmologica. Advances in ophthalmology · 2026Review
- CaActa physiologica (Oxford, England) · 2026Review
- L-type CaProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Calcium Channels in Retinal Function and Disease.Annual review of vision science · 2022Review
- T-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Structure and Function of the Bestrophin family of calcium-activated chloride channels.Channels (Austin, Tex.) · 2021Review
- Preventing diabetic retinopathy by mitigating subretinal space oxidative stressVisual neuroscience · 2020Review
- Circadian regulation in the retina: From molecules to network.The European journal of neuroscience · 2020Review
- CaeLife · 2019Article
- The Contribution of L-Type CaFrontiers in molecular neuroscience · 2017Article
- Early Functional and Morphologic Abnormalities in the Diabetic Nyxnob Mouse Retina.Investigative ophthalmology & visual science · 2016Article
- MRI of rod cell compartment-specific function in disease and treatment in vivo.Progress in retinal and eye research · 2016Review
- Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.Investigative ophthalmology & visual science · 2015Article
- Bestrophin-1 influences transepithelial electrical properties and Ca2+ signaling in human retinal pigment epithelium.Molecular vision · 2015Article
- L-type CaWiley interdisciplinary reviews. Membrane transport and signaling · 2014Article
- What can naturally occurring mutations tell us about Ca(v)1.x channel function?Biochimica et biophysica acta · 2013Review
- Role of bestrophin-1 in store-operated calcium entry in retinal pigment epithelium.Pflugers Archiv : European journal of physiology · 2013Article
- Article
- Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia.Experimental eye research · 2012Article
- The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins.Visual neuroscience · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
In response to light, the mouse retinal pigment epithelium (RPE) generates a series of slow changes in potential that are referred to as the c-wave, fast oscillation (FO), and light peak (LP) of the electroretinogram (ERG). The LP is generated by a depolarization of the basolateral RPE plasma membrane by the activation of a calcium-sensitive chloride conductance. We have previously shown that the LP is reduced in both mice and rats by nimodipine, which blocks voltage-dependent calcium channels (VDCCs) and is abnormal in lethargic mice, carrying a null mutation in the calcium channel beta(4) subunit. To define the alpha(1) subunit involved in this process, we examined mice lacking Ca(V)1.3. In comparison with wild-type (WT) control littermates, LPs were reduced in Ca(V)1.3(-/-) mice. This pattern matched closely with that previously noted in lethargic mice, confirming a role for VDCCs in regulating the signaling pathway that culminates in LP generation. These abnormalities do not reflect a defect in rod photoreceptor activity, which provides the input to the RPE to generate the c-wave, FO, and LP, because ERG a-waves were comparable in WT and Ca(V)1.3(-/-) littermates. Our results identify Ca(V)1.3 as the principal pore-forming subunit of VDCCs involved in stimulating the ERG LP.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.