ArticleExperimental cell research2007
Organization of cytokeratin cytoskeleton and germ plasm in the vegetal cortex of Xenopus laevis oocytes depends on coding and non-coding RNAs: three-dimensional and ultrastructural analysis.
Article in Experimental cell research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Organizing the oocyte: RNA localization meets phase separation.Current topics in developmental biology · 2020Article
- Maintenance of Miranda Localization in Drosophila Neuroblasts Involves Interaction with the Cognate mRNA.Current biology : CB · 2017Article
- Maternal RNA regulates Aurora C kinase during mouse oocyte maturation in a translation-independent fashion.Biology of reproduction · 2017Article
- Maternal messages to live by: a personal historical perspective.Genesis (New York, N.Y. : 2000) · 2017Review
- cncRNAs: Bi-functional RNAs with protein coding and non-coding functions.Seminars in cell & developmental biology · 2015Review
- RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor.Developmental biology · 2015Article
- Intracellular microRNA profiles form in the Xenopus laevis oocyte that may contribute to asymmetric cell division.Scientific reports · 2015Article
- oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction.RNA (New York, N.Y.) · 2015Article
- The Xenopus Maternal-to-Zygotic Transition from the Perspective of the Germline.Current topics in developmental biology · 2015Review
- Long noncoding RNAs as metazoan developmental regulators.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- Long non-coding RNAs (lncRNAs) and viral infections.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2013Article
- Article
- Insulin-producing cells from adult human bone marrow mesenchymal stem cells control streptozotocin-induced diabetes in nude mice.Cell transplantation · 2013Article
- Protein interactions in Xenopus germ plasm RNP particles.PloS one · 2013Article
- New insights into the regulation of RNP granule assembly in oocytes.International review of cell and molecular biology · 2012Review
- RNA granules in germ cells.Cold Spring Harbor perspectives in biology · 2011Review
- The roles of maternal Vangl2 and aPKC in Xenopus oocyte and embryo patterning.Development (Cambridge, England) · 2011Article
- The use of antisense oligonucleotides in Xenopus oocytes.Methods (San Diego, Calif.) · 2010Review
- Long noncoding RNAs: functional surprises from the RNA world.Genes & development · 2009Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Recent studies discovered a novel structural role of RNA in maintaining the integrity of the mitotic spindle and cellular cytoskeleton. In Xenopus laevis, non-coding Xlsirts and coding VegT RNAs play a structural role in anchoring localized RNAs, maintaining the organization of the cytokeratin cytoskeleton and germinal granules in the oocyte vegetal cortex and in subsequent development of the germline in the embryo. We studied the ultrastructural effects of antisense oligonucleotide driven ablation of Xlsirts and VegT RNAs on the organization of the cytokeratin, germ plasm and other components of the vegetal cortex. We developed a novel method to immunolabel and visualize cytokeratin at the electron microscopy level, which allowed us to reconstruct the ultrastructural organization of the cytokeratin network relative to the components of the vegetal cortex in Xenopus oocytes. The removal of Xlsirts and VegT RNAs not only disrupts the cytokeratin cytoskeleton but also has a profound transcript-specific effect on the anchoring and distribution of germ plasm islands and their germinal granules and the arrangement of yolk platelets within the vegetal cortex. We suggest that the cytokeratin cytoskeleton plays a role in anchoring of germ plasm islands within the vegetal cortex and germinal granules within the germ plasm islands.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.