Trial reportBMC cardiovascular disorders2007
Flow mediated dilation of the brachial artery: an investigation of methods requiring further standardization.
Trial report in BMC cardiovascular disorders, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test.Journal of visualized experiments : JoVE · 2016Guideline
- Assessment of flow-mediated dilation in humans: a methodological and physiological guideline.American journal of physiology. Heart and circulatory physiology · 2011 · on this mapGuideline
- AltilixNutrients · 2019Trial
- Endothelial function following interval exercise plus low-calorie diet treatment in obese females.Physiological reports · 2019Trial
- Sickle cell microvascular paradox-oxygen supply-demand mismatch.American journal of hematology · 2019Trial
- Pretreatment with Antioxidants Augments the Acute Arterial Vasoconstriction Caused by Diesel Exhaust Inhalation.American journal of respiratory and critical care medicine · 2016Trial
- A Pilot Study to Determine if Vitamin D Repletion Improves Endothelial Function in Lupus Patients.The American journal of the medical sciences · 2015Trial
- A lifestyle intervention supported by mobile health technologies to improve the cardiometabolic risk profile of individuals at risk for cardiovascular disease and type 2 diabetes: study rationale and protocol.BMC public health · 2013Trial
- Doppler assessment of brachial artery flow as a measure of endothelial dysfunction in pediatric chronic renal failure.Pediatric nephrology (Berlin, Germany) · 2008Trial
- Diesel exhaust inhalation elicits acute vasoconstriction in vivo.Environmental health perspectives · 2008Trial
- Effects of GlucoerbJournal of clinical medicine · 2026Article
- Article
- Monitoring of Tissue Perfusion During Arterial Occlusion With Remote Photoplethysmographic Imaging.Journal of biophotonics · 2026Article
- Influence of Arterial Occlusion at Various Cuff Positions on Systemic Circulation Measured by Remote Photoplethymography (rPPG).Advances in experimental medicine and biology · 2026Article
- Cardiorespiratory and vascular function outcomes following 4 weeks of single-sprint training.Frontiers in physiology · 2026Article
- Myeloperoxidase impacts vascular function by altering perivascular adipocytes' secretome and phenotype in obesity.Cell reports. Medicine · 2025Article
- Brachial artery flow-mediated dilation in patients with systemic sclerosis: an experience from tertiary care center from North India.Clinical rheumatology · 2023Article
- Article
- Age-Dependent Decline in Common Femoral Artery Flow-Mediated Dilation and Wall Shear Stress in Healthy Subjects.Life (Basel, Switzerland) · 2022Article
- Mapping Pulsatile Optic Nerve Head Deformation Using OCT.Ophthalmology science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIn order to establish a consistent method for brachial artery reactivity assessment, we analyzed commonly used approaches to the test and their effects on the magnitude and time-course of flow mediated dilation (FMD), and on test variability and repeatability. As a popular and noninvasive assessment of endothelial function, several different approaches have been employed to measure brachial artery reactivity with B-mode ultrasound. Despite some efforts, there remains a lack of defined normal values and large variability in measurement technique.
methodsTwenty-six healthy volunteers underwent repeated brachial artery diameter measurements by B-mode ultrasound. Following baseline diameter recordings we assessed endothelium-dependent flow mediated dilation by inflating a blood pressure cuff either on the upper arm (proximal) or on the forearm (distal).
resultsThirty-seven measures were performed using proximal occlusion and 25 with distal occlusion. Following proximal occlusion relative to distal occlusion, FMD was larger (16.2 +/- 1.2% vs. 7.3 +/- 0.9%, p < 0.0001) and elongated (107.2 s vs. 67.8 s, p = 0.0001). Measurement of the test repeatability showed that differences between the repeated measures were greater on average when the measurements were done using the proximal method as compared to the distal method (2.4%; 95% CI 0.5-4.3; p = 0.013).
conclusionThese findings suggest that forearm compression holds statistical advantages over upper arm compression. Added to documented physiological and practical reasons, we propose that future studies should use forearm compression in the assessment of endothelial function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.