ArticleImmunity & ageing : I & A2007
Role of persistent CMV infection in configuring T cell immunity in the elderly.
Article in Immunity & ageing : I & A, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 98 citations in OpenAlex.
- Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster.PloS one · 2018Trial
- Cardiovascular exercise intervention improves the primary antibody response to keyhole limpet hemocyanin (KLH) in previously sedentary older adults.Brain, behavior, and immunity · 2008Trial
- Human Immunodeficiency Virus (HIV)-Negative Men Who Have Sex With Men Have Higher CD8+ T-Cell Counts and Lower CD4+/CD8+ T-Cell Ratios Compared With HIV-Negative Heterosexual Men.The Journal of infectious diseases · 2021Article
- Induction of T Cell Senescence by Cytokine Induced Bystander Activation.Frontiers in aging · 2021Review
- The untwining of immunosenescence and aging.Seminars in immunopathology · 2020Review
- Early T Cell Differentiation with Well-Maintained Function across the Adult Life Course in Sub-Saharan Africa.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Anti-cytomegalovirus IgG antibody titer is positively associated with advanced T cell differentiation and coronary artery disease in end-stage renal disease.Immunity & ageing : I & A · 2018Article
- Checks and Balances in Autoimmune Vasculitis.Frontiers in immunology · 2018Review
- Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?Frontiers in immunology · 2017Review
- Immunosenescence in aging: between immune cells depletion and cytokines up-regulation.Clinical and molecular allergy : CMA · 2017Review
- γδ T Cell-Mediated Immunity to Cytomegalovirus Infection.Frontiers in immunology · 2017Review
- T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment.The Journal of infectious diseases · 2016Article
- Shifts in subsets of CD8+ T-cells as evidence of immunosenescence in patients with cancers affecting the lungs: an observational case-control study.BMC cancer · 2015Observational
- Human Cytomegalovirus UL135 and UL136 Genes Are Required for Postentry Tropism in Endothelial Cells.Journal of virology · 2015Article
- Cytomegalovirus infection enhances the immune response to influenza.Science translational medicine · 2015Article
- Article
- Next Generation Vaccine Biomarkers workshop October 30-31, 2014--Ottawa, Canada.Human vaccines & immunotherapeutics · 2015Article
- Complex expression of the UL136 gene of human cytomegalovirus results in multiple protein isoforms with unique roles in replication.Journal of virology · 2014Article
- Latent infection of human cytomegalovirus is associated with the development of gastric cancer.Oncology letters · 2014Article
- Antagonistic determinants controlling replicative and latent states of human cytomegalovirus infection.Journal of virology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ageing is associated with declines in many physiological parameters, including multiple immune system functions. The rate of acceleration of the frequency of death due to cardiovascular disease or cancer seems to increase with age from middle age up to around 80 years, plateauing thereafter. Mortality due to infectious disease, however, does not plateau, but continues to accelerate indefinitely. The elderly commonly possess oligoclonal expansions of T cells, especially of CD8 cells, which, surprisingly, are often associated with cytomegalovirus (CMV) seropositivity. This in turn is associated with many of the same phenotypic and functional alterations to T cell immunity that have been suggested as biomarkers of immune system aging. Thus, the manner in which CMV and the host immune system interact is critical in determining the "age" of specific immunity. We may therefore consider immunosenescence in some respects as an infectious state. This implies that interventions aimed at the pathogen may improve the organ system affected. Hence, CMV-directed anti-virals or vaccination may have beneficial effects on immunity in later life.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.