ArticleInternational journal of mass spectrometry2007
Comparative Bioinformatics Analyses and Profiling of Lysosome-Related Organelle Proteomes.
Article in International journal of mass spectrometry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
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- Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.Molecular biology of the cell · 2013Article
- Bioanalysis of eukaryotic organelles.Chemical reviews · 2013Review
- Mouse RC/BTB2, a member of the RCC1 superfamily, localizes to spermatid acrosomal vesicles.PloS one · 2012Article
- Systems biology of the autophagy-lysosomal pathway.Autophagy · 2011Article
- Acrosome biogenesis: Revisiting old questions to yield new insights.Spermatogenesis · 2011Article
- Comparative proteomic analysis of lung lamellar bodies and lysosome-related organelles.PloS one · 2011Article
- Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells.Cell communication and signaling : CCS · 2011Article
- Omics-based molecular target and biomarker identification.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism.The Journal of biological chemistry · 2010Article
- The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans.Molecular biology of the cell · 2010Article
- Protein Bioinformatics Infrastructure for the Integration and Analysis of Multiple High-Throughput "omics" Data.Advances in bioinformatics · 2010Article
- Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells.Journal of proteomics · 2009Article
- Subcellular proteomics of Trypanosoma cruzi reservosomes.Proteomics · 2009Article
- Proteomics in Trypanosoma cruzi--localization of novel proteins to various organelles.Proteomics · 2008Article
- Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data.Journal of proteomics & bioinformatics · 2008Article
- Modifying skin pigmentation - approaches through intrinsic biochemistry and exogenous agents.Drug discovery today. Disease mechanisms · 2008Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Complete and accurate profiling of cellular organelle proteomes, while challenging, is important for the understanding of detailed cellular processes at the organelle level. Mass spectrometry technologies coupled with bioinformatics analysis provide an effective approach for protein identification and functional interpretation of organelle proteomes. In this study, we have compiled human organelle reference datasets from large-scale proteomic studies and protein databases for 7 lysosome-related organelles (LROs), as well as the endoplasmic reticulum and mitochondria, for comparative organelle proteome analysis. Heterogeneous sources of human organelle proteins and rodent homologs are mapped to human UniProtKB protein entries based on ID and/or peptide mappings, followed by functional annotation and categorization using the iProXpress proteomic expression analysis system. Cataloging organelle proteomes allows close examination of both shared and unique proteins among various LROs and reveals their functional relevance. The proteomic comparisons show that LROs are a closely related family of organelles. The shared proteins indicate the dynamic and hybrid nature of LROs, while the unique transmembrane proteins may represent additional candidate marker proteins for LROs. This comparative analysis, therefore, provides a basis for hypothesis formulation and experimental validation of organelle proteins and their functional roles.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.