ArticleCurrent microbiology2007
The CrdRS (HP1365-HP1364) two-component system is not involved in ph-responsive gene regulation in the Helicobacter pylori Strains 26695 and G27.
Article in Current microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Gene Expression Profiling of Transcription Factors ofFrontiers in microbiology · 2017Article
- Role of the Helicobacter pylori sensor kinase ArsS in protein trafficking and acid acclimation.Journal of bacteriology · 2012Article
- Gastric infection by Helicobacter pylori.Current gastroenterology reports · 2009Review
- Histidine residue 94 is involved in pH sensing by histidine kinase ArsS of Helicobacter pylori.PloS one · 2009Article
- Article
- The pH-responsive regulon of HP0244 (FlgS), the cytoplasmic histidine kinase of Helicobacter pylori.Journal of bacteriology · 2009Article
- Helicobacter pylori HopQ outer membrane protein attenuates bacterial adherence to gastric epithelial cells.FEMS microbiology letters · 2008Article
- Development of inducible systems to engineer conditional mutants of essential genes of Helicobacter pylori.Applied and environmental microbiology · 2008Article
- Polymorphisms of the acid sensing histidine kinase gene arsS in Helicobacter pylori populations from anatomically distinct gastric sites.Microbial pathogenesisArticle
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Authors and funding
3 authors.
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Abstract
The human gastric pathogen Helicobacter pylori is extremely well adapted to the highly acidic conditions encountered in the stomach. The pronounced acid resistance of H. pylori relies mainly on the ammonia-producing enzyme urease. However, urease-independent mechanisms are likely to contribute to acid adaptation. pH-responsive gene regulation in this organism is mediated by a two-component system (HP0166-HP0165) designated ArsRS and the metal-dependent regulators NikR and Fur. Recently, it was reported that another two-component system termed CrdRS (HP1365-HP1364) is required for pH-responsive regulation of the major acid-resistance systems in the H. pylori strain J99. By the analysis of crdRS null mutants of the H. pylori strains 26695 and G27, we show that low pH induction of both the urease and the amidase genes occurs in the absence of crdRS in these strains, suggesting substantial strain-specific differences in the regulation of a major virulence determinant.
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