ArticlePediatric nephrology (Berlin, Germany)2007
Diagnostic significance of clinical and laboratory findings to localize site of urinary infection.
Article in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children.The Cochrane database of systematic reviews · 2020Pooled it
- Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children.The Cochrane database of systematic reviews · 2015Pooled it
- Biomarkers for urinary tract infection: present and future perspectives.Pediatric nephrology (Berlin, Germany) · 2024Review
- Plasma and Urinary Neutrophil Gelatinase-Associated Lipocalin as Predictors of Renal Parenchymal Involvement in Children with Febrile Urinary Tract Infection: A Pilot Study.Children (Basel, Switzerland) · 2024Article
- Febrile Urinary Tract Infections in Children: The Role of High Mobility Group Box-1.Children (Basel, Switzerland) · 2022Article
- MR-Proadrenomedullin as biomarker of renal damage in urinary tract infection in children.BMC pediatrics · 2021Article
- Serum Interleukin-6 and Interleukin-8 are Sensitive Markers for Early Detection of Pyelonephritis and Its Prevention to Progression to Chronic Kidney Disease.International journal of preventive medicine · 2021Article
- Differential Serum and Urine CRP, IP-10, and TRAIL Levels in Pediatric Urinary Tract Infection.Frontiers in pediatrics · 2021Article
- Urinary carbohydrate antigen 19-9 level as a biomarker in children with acute pyelonephritis.European journal of pediatrics · 2020Article
- Comparison of Tc-99m DMSA Renal Planar Scan and SPECT for Detection of Cortical Defects in Infants with Suspected Acute Pyelonephritis.Indian journal of pediatrics · 2019Article
- D-dimer as a marker of acute pyelonephritis in infants younger than 24 months with urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2018Article
- Plasma neutrophil gelatinase-associated lipocalin: a marker of acute pyelonephritis in children.Pediatric nephrology (Berlin, Germany) · 2017Article
- [Imaging in urinary tract infections in childhood].Der Radiologe · 2016Review
- Prediction of Cortical Defect Using C-Reactive Protein and Urine Sodium to Potassium Ratio in Infants with Febrile Urinary Tract Infection.Yonsei medical journal · 2016Article
- Decreased concentrating capacity in children with febrile urinary tract infection and normal 99mTc-dimercaptosuccinic acid scan: does medullonephritis exist?World journal of pediatrics : WJP · 2014Article
- Do serum C-reactive protein and interleukin-6 predict kidney scarring after urinary tract infection?Indian journal of pediatrics · 2013Observational
- Diagnostic Accuracy of the Quantitative C-Reactive Protein, Erythrocyte Sedimentation Rate and White Blood Cell Count in Urinary Tract Infections among Infants and Children.The Malaysian journal of medical sciences : MJMS · 2013Article
- Different imaging strategies in febrile urinary tract infection in childhood. What, when, why?Pediatric radiology · 2013Article
- [Diagnostics and therapy of urinary tract infections].Der Urologe. Ausg. A · 2013Article
- Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection.BMC pediatrics · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to define in children younger than 2 years of age the diagnostic significance of clinical and laboratory findings to localize site of febrile urinary tract infection. We reviewed the records of 185 children younger than 2 years of age admitted to hospital with febrile urinary tract infection. Patients were divided into having either acute pyelonephritis or acute cystitis according to the presence or absence of acute lesions on dimercaptosuccinic acid (DMSA) renal scintigraphy. Clinical and laboratory [white blood cell count (WBC), urinalysis, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)] findings were compared between the two groups using Student's t test, chi-square test, and multivariate analysis. Patients with pyelonephritis had statistically significant higher age, WBC, ESR, and CRP than those with cystitis. Although the sensitivity of the tests was 80-100%, their specificity was <28%. On multivariate analysis, 33% of patients with cystitis were diagnosed as having pyelonephritis, whereas 22% of those with pyelonephritis were considered to have cystitis. Given the low specificity of clinical findings and available laboratory tests to define the site of urine infection in this age group, we recommend DMSA renal scintigram as the test of choice to make the diagnosis of acute pyelonephritis in these patients.
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Registered trials
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