ArticleJournal of neurology2007
Brain perfusion correlates of medial temporal lobe atrophy and white matter hyperintensities in mild cognitive impairment.
Article in Journal of neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Intracranial atherosclerosis increases risk of incident dementia in middle-aged general population.Chinese medical journal · 2026Article
- Cerebral amyloid-β, glucose metabolism and hippocampal volume in major depression with and without suspected non-Alzheimer pathophysiology (SNAP).Alzheimer's research & therapy · 2025Article
- Sex differences in sleep apnea and Alzheimer's Disease: role of cerebrovascular dysfunction.npj women's health · 2025Review
- SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia.CNS neuroscience & therapeutics · 2024Article
- The Utility of Arterial Spin Labeling MRI in Medial Temporal Lobe as a Vascular Biomarker in Alzheimer's Disease Spectrum: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function.Journal of neuroinflammation · 2021Article
- Effects of Process-Based Cognitive Training on Memory in the Healthy Elderly and Patients with Mild Cognitive Impairment: A Randomized Controlled Trial.Psychiatry investigation · 2020Article
- Electroencephalography-driven approach to prodromal Alzheimer's disease diagnosis: from biomarker integration to network-level comprehension.Clinical interventions in aging · 2016Article
- Conversion of mild cognitive impairment patients in Alzheimer's disease: prognostic value of Alpha3/Alpha2 electroencephalographic rhythms power ratio.Alzheimer's research & therapy · 2015Article
- White matter signal abnormality quality differentiates mild cognitive impairment that converts to Alzheimer's disease from nonconverters.Neurobiology of aging · 2015Article
- Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer's disease.Neuropsychiatric disease and treatment · 2015Article
- Electroencephalography reveals lower regional blood perfusion and atrophy of the temporoparietal network associated with memory deficits and hippocampal volume reduction in mild cognitive impairment due to Alzheimer's disease.Neuropsychiatric disease and treatment · 2015Article
- Mild Cognitive Impairment: Structural, Metabolical, and Neurophysiological Evidence of a Novel EEG Biomarker.Frontiers in neurology · 2015Review
- Atrophy and lower regional perfusion of temporo-parietal brain areas are correlated with impairment in memory performances and increase of EEG upper alpha power in prodromal Alzheimer's disease.American journal of neurodegenerative disease · 2015Article
- Understanding early dementia: EEG, MRI, SPECT and memory evaluation.Translational neuroscience · 2015Article
- Diagnostic accuracy of markers for prodromal Alzheimer's disease in independent clinical series.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013Article
- Glucose metabolism in normal aging and Alzheimer's disease: Methodological and physiological considerations for PET studies.Clinical and translational imaging · 2013Article
- Increase of theta frequency is associated with reduction in regional cerebral blood flow only in subjects with mild cognitive impairment with higher upper alpha/low alpha EEG frequency power ratio.Frontiers in behavioral neuroscience · 2013Article
- Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2011Article
- Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain.Stroke · 2010Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the association of Medial Temporal lobe Atrophy (MTA) and White Matter Hyperintensities (WMHs) with gray matter perfusion in Mild Cognitive Impairment (MCI).
methods56 MCI patients (age = 69.3 +/- 7.0, 32 females) underwent brain MR scan and (99m)Tc ECD SPECT. We evaluated MTA according to Scheltens' fivepoint scale on T1 MR images, and assessed WMHs using the rating scale for age-related white matter changes on T2-weighted and FLAIR MR images. We divided MCI into age-matched subgroups with high and low MTA and high and low WMHs load. We processed SPECT images with SPM2 following an optimized protocol and performed a voxel-based statistical analysis comparing high vs. low MTA and high vs. low WMHs, setting p-value at 0.001 uncorrected, thresholding cluster extent at 100 voxels, using proportional scaling and entering age and WMHs or MTA respectively as nuisance covariates.
resultsMCI with high compared with low MTA showed hypoperfusion in the left hippocampus and in the left parahippocampal gyrus. MCI with high compared with low WMHs showed a hypoperfusion area in the left insular region and superior temporal gyrus.
conclusionsMTA in MCI is associated with hippocampal gray matter hypoperfusion while WMHs is associated with gray matter hypoperfusion in areas of the insula and temporal neocortex. These results confirm that MTA is associated with local functional changes and suggest that WMHs may be associated with remote brain cortical dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.