ArticlePloS one2007
Genes involved in the balance between neuronal survival and death during inflammation.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging.bioRxiv : the preprint server for biology · 2026Article
- Hypocortisolemic ASIA: a vaccine- and chronic infection-induced syndrome behind the origin of long COVID and myalgic encephalomyelitis.Frontiers in immunology · 2024Review
- Systems modeling of white matter microstructural abnormalities in Alzheimer's disease.NeuroImage. Clinical · 2020Article
- Establishment of minimal positive-control conditions to ensure brain safety during rapid development of emergency vaccines.Journal of veterinary science · 2017Article
- IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.Frontiers in neurology · 2017Article
- Gene Expression Control by Glucocorticoid Receptors during Innate Immune Responses.Frontiers in endocrinology · 2016Review
- Article
- TLR4-mediated brain inflammation halts neurogenesis: impact of hormonal replacement therapy.Frontiers in cellular neuroscience · 2014Article
- Absence of TLR4 reduces neurovascular unit and secondary inflammatory process after traumatic brain injury in mice.PloS one · 2013Article
- Innate immunity and neuroinflammation.Mediators of inflammation · 2013Review
- System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo.Experimental neurology · 2012Article
- Vascular Pathology as a Potential Therapeutic Target in SCI.Translational stroke research · 2011Article
- Lipocalin 2 plays an immunomodulatory role and has detrimental effects after spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Comparative tissue transcriptomics reveal prompt inter-organ communication in response to local bacterial kidney infection.BMC genomics · 2011Article
- The Neural/Immune Gene Ontology: clipping the Gene Ontology for neurological and immunological systems.BMC bioinformatics · 2010Article
- A robust procedure for comparing multiple means under heteroscedasticity in unbalanced designs.PloS one · 2010Article
- Iron is essential for oligodendrocyte genesis following intraspinal macrophage activation.Experimental neurology · 2009Article
- Regulation of innate immune responses in the brain.Nature reviews. Immunology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucocorticoids are potent regulators of the innate immune response, and alteration in this inhibitory feedback has detrimental consequences for the neural tissue. This study profiled and investigated functionally candidate genes mediating this switch between cell survival and death during an acute inflammatory reaction subsequent to the absence of glucocorticoid signaling. Oligonucleotide microarray analysis revealed that following lipopolysaccharide (LPS) intracerebral administration at striatum level, more modulated genes presented transcription impairment than exacerbation upon glucocorticoid receptor blockage. Among impaired genes we identified ceruloplasmin (Cp), which plays a key role in iron metabolism and is implicated in a neurodegenative disease. Microglial and endothelial induction of Cp is a natural neuroprotective mechanism during inflammation, because Cp-deficient mice exhibited increased iron accumulation and demyelination when exposed to LPS and neurovascular reactivity to pneumococcal meningitis. This study has identified genes that can play a critical role in programming the innate immune response, helping to clarify the mechanisms leading to protection or damage during inflammatory conditions in the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.