ArticleRespiratory physiology & neurobiology2007
Age-related changes in the serotonin 2A receptor in the hypoglossal nucleus of male and female rats.
Article in Respiratory physiology & neurobiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Sex-related differences in motoneuron firing behavior during typical development.Journal of neurophysiology · 2025Article
- Age-related sex differences in tongue strength and muscle morphometry in a rat model.Archives of oral biology · 2023Article
- Social regulation of serotonin in the auditory midbrain.Behavioral neuroscience · 2011Article
- Measures of bulbar and spinal motor function, muscle innervation, and mitochondrial function in ALS rats.Behavioural brain research · 2010Article
- Hypoxic and hypercapnic ventilatory responses in aging male vs. aging female rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- The effects of aging on hypoglossal motoneurons in rats.Dysphagia · 2009Article
- Serotonergic projections from the caudal raphe nuclei to the hypoglossal nucleus in male and female rats.Respiratory physiology & neurobiology · 2009Article
- Sex steroidal hormones and respiratory control.Respiratory physiology & neurobiology · 2008Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hypoglossal motoneuron output to the genioglossus muscle contributes to upper airway patency. Serotonin (5HT) plays an important role in regulating hypoglossal motoneuron excitability via serotonin 2A receptors (5HT(2A)). The purpose of this study was to investigate whether there are age-associated changes in 5HT(2A) receptor expression in the hypoglossal nucleus of male and female rats. The brains of young, middle-aged and old F344 rats were sectioned, reacted immunocytochemically for the presence of 5HT(2A) receptor, and the staining density quantified. The estrus stage of female rats was determined and circulating sex hormone levels measured and correlated with 5HT(2A) levels. The results show that there was significantly greater 5HT(2A) receptor immunoreactivity in the hypoglossal nucleus of female than of male rats. With increasing age, there was an increase in 5HT(2A) receptor immunoreactivity in the hypoglossal nucleus of female rats, whereas no age-associated changes were observed in male rats. Previous studies have shown a reduction in 5HT-dependent respiratory plasticity and an age-associated decrease in 5HT in the hypoglossal nucleus in male but not female rats. Data from the present study suggest that aging male rats fail to compensate adequately for reduced 5HT in the hypoglossal nucleus by upregulating the expression of the 5HT(2A) receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.