ArticleWorld journal of gastroenterology2007
Possible role of human cytomegalovirus in pouchitis after proctocolectomy with ileal pouch-anal anastomosis in patients with ulcerative colitis.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Common Inflammatory Disorders and Neoplasia of the Ileal Pouch: A Review of Histopathology.Gastroenterology research · 2016Review
- Inflammatory pouch disease: The spectrum of pouchitis.World journal of gastroenterology · 2015Review
- Protracted primary cytomegalovirus infection presenting as ileoanal pouchitis in a non-immunosuppressed patient: a case report.Journal of medical case reports · 2014Article
- Cytomegalovirus infection of the ileoanal pouch: clinical characteristics and outcomes.Inflammatory bowel diseases · 2013Article
- Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease.World journal of gastroenterology · 2013Article
- Natural history of cytomegalovirus infection in a series of patients diagnosed with moderate-severe ulcerative colitis.World journal of gastroenterology · 2011Article
- Diagnosis and management of pouchitis and ileoanal pouch dysfunction.Current gastroenterology reports · 2010Review
- The bacterial pathogenesis and treatment of pouchitis.Therapeutic advances in gastroenterology · 2010Article
- Diagnosis and treatment of pouchitis.Gastroenterology & hepatology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo detect the presence of human cytomegalovirus (HCMV) proteins and genes on the ileal pouch of patients with ulcerative colitis who have undergone proctocolectomy with ileal pouch-anal anastomosis (IPAA).
methodsImmunohistochemistry, polymerase chain reaction (PCR) and PCR sequencing methods were utilized to test the presence of HCMV in pouch specimens taken from 34 patients in 86 endoscopies.
resultsHCMV genes and proteins were detected in samples from 12 (35.2%) patients. The rate of detection was significant in the endoscopies from patients diagnosed with pouchitis (5 of 12, 41.6%), according to the Japanese classification of pouchitis, in comparison to patients with normal pouch (7 of 62, 11.2%; P = 0.021). In all patients with pouchitis in which the HCMV was detected, it was the first episode of pouchitis. The virus was not detected in previous biopsies taken in normal endoscopies of these patients. During the follow-up, HCMV was detected in one patient with recurrent pouchitis and in 3 patients whose pouchitis episodes improved but whose positive endoscopic findings persisted.
conclusionHCMV can take part in the inflammatory process of the pouch in some patients with ulcerative colitis who have undergone proctocolectomy with IPAA.
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