ArticleWorld journal of gastroenterology2007
Decreased fragile histidine triad expression in colorectal cancer and its association with apoptosis inhibition.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Livin serves as a prognostic marker for mid-distal rectal cancer and a target of mid-distal rectal cancer treatment.Oncology letters · 2017Article
- Fhit down-regulation is an early event in pancreatic carcinogenesis.Virchows Archiv : an international journal of pathology · 2017Article
- Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease.Cancer research · 2016Article
- Transcriptional regulation of the survivin gene.Molecular biology reports · 2014Review
- Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Aberrant crypt focus and fragile histidine triad protein in sporadic colorectal carcinoma.World journal of gastrointestinal oncology · 2012Article
- Correlation of aberrant expression of CD133 with FHIT and malignant phenotype of colorectal adenocarcinoma.International journal of colorectal disease · 2012Article
- Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical features.Annals of surgical oncology · 2009Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo detect the expression of fragile histidine triad (FHIT) in normal colorectal tissue, colorectal adenoma and colorectal cancer (CRC) tissue, and to analyze its relationship with the clinicopathological features of CRC, and apoptosis-associated proteins (Bcl-2, Bax, survivin) and apoptosis in colorectal cancer.
methodsFHIT mRNA analysis was performed by nested reverse transcription-polymerase chain reaction (RT-PCR) assay. Tissue microarray (TMA) was established to detect the expression of FHIT, Bcl-2, Bax and survivin genes in 80 CRC tissue specimens, 16 colorectal adenoma tissue specimens and 16 hemorrhoid (PPH) tissue specimens during the same period of time as the control. Citrate-microwave-SP was used as immunohistochemical method. The relationship between clinicopathological factors, such as differentiation grades and 5-year survival rate was observed. TUNEL assay was used to detect the apoptosis index in 80 CRC tissue specimens.
resultsTen out of 26 (38.5%) CRC tissue specimens expressed aberrant FHIT transcripts, none of the aberrant FHIT transcripts was observed in the matched normal tissue and colorectal adenoma tissue by nested RT-PCR assay. The positive rate of FHIT gene expression in normal colorectal tissue, colorectal adenoma and carcinoma tissue was 93.75%, 68.75% and 46.25%, respectively. Clinicopathological analysis of patients showed that the decreased FHIT gene expression was not associated with age, sex, serum CEA levels, tumor site and size, histological classification. However, the expression of FHIT was correlated with differentiation grades, pathological stages, lymph node metastases and 5-year survival rate after operation. The positive rate of apoptosis-associated proteins (Bax, Bcl-2 and survivin) in CRC tissue was 72.50%, 51.25% and 77.50%, respectively. The expression of these apoptosis-associated proteins in CRC tissue was correlated with the expression of FHIT. The mean apoptosis index in FHIT negative tumors was significantly lower than that in FHIT positive tumors (5.41 +/- 0.23 vs 0.56 +/- 0.10, P < 0.01).
conclusionThe FHIT gene plays an important role in the regulation of apoptosis and decreased FHIT expression plays a key role in the initiation and progression of colorectal carcinoma.
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