ArticlePharmaceutical research2007
Direct observation of single particle electrostatic charging by atomic force microscopy.
Article in Pharmaceutical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Influence of Wettability and Geometry on Contact Electrification between Nonionic Insulators.ACS applied materials & interfaces · 2023Article
- Assessment of Tribo-charging and Continuous Feeding Performance of Direct Compression Grades of Isomalt and Mannitol Powders.AAPS PharmSciTech · 2023Article
- Article
- An Evaluation System for the Contact Electrification of a Single Microparticle Using Microelectromechanical-Based Actuated Tweezers.Sensors (Basel, Switzerland) · 2018Article
- Friction coefficient dependence on electrostatic tribocharging.Scientific reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo show that atomic force microscopy (AFM) can be used to directly study the electrostatic charging and dissipation of single pharmaceutical particles. MATERIALS AND
methodsParticles of lactose attached to AFM cantilevers were charged on a glass surface at a relative humidity (RH) of 0.1%. By recording force-distance curves, we use a measurement of the long range electrostatic interaction to compare the generation of charge by contact charging and tribocharging and to study the effect of RH on charge dissipation.
resultsAs expected, tribocharging by scanning the particle across the glass surface generates considerably more charge than repeated local contacts. Increasing the RH from 0.1 to 5% over a period of 37 min dissipates the tribo-generated electrostatic charge.
conclusionsUsing a combination of the abilities of AFM to scan in contact mode and record force-distance curves, we have shown a novel method to study electrostatic charging of particles. By measuring the length of the long range electrostatic interaction, we are able to compare different mechanisms of generating charge and to study the effect of RH on charge dissipation.
Indexed as
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17373580What OpenQuestion holds
Registered trials
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