ArticlePharmaceutical research2007
Development and validation of a physiology-based model for the prediction of oral absorption in monkeys.
Article in Pharmaceutical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 52 citations in OpenAlex.
- Improving In Vitro-In Vivo Correlation (IVIVC) for Lipid-Based Formulations: Overcoming Challenges and Exploring Opportunities.Pharmaceutics · 2025Review
- PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab.Frontiers in pharmacology · 2024Article
- Simulation Models for Prediction of Bioavailability of Medicinal Drugs-the Interface Between Experiment and Computation.AAPS PharmSciTech · 2022Review
- A workflow to build PBTK models for novel species.Archives of toxicology · 2020Article
- The Segregated Intestinal Flow Model (SFM) for Drug Absorption and Drug Metabolism: Implications on Intestinal and Liver Metabolism and Drug-Drug Interactions.Pharmaceutics · 2020Review
- A physiologically based pharmacokinetic model of the minipig: data compilation and model implementation.Pharmaceutical research · 2013Review
- Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling.British journal of clinical pharmacology · 2012Article
- A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.Frontiers in physiology · 2011Article
- Mechanistic approaches to predicting oral drug absorption.The AAPS journal · 2009Review
- Drug absorption modeling as a tool to define the strategy in clinical formulation development.The AAPS journal · 2008Review
- Towards quantitative prediction of oral drug absorption.Clinical pharmacokinetics · 2008Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe development and validation of a physiology-based absorption model for orally administered drugs in monkeys is described. MATERIALS AND
methodsPhysiological parameters affecting intestinal transit and absorption of an orally administered drug in monkeys have been collected from the literature and implemented in a physiological model for passive absorption previously developed for rats and humans. Predicted fractions of dose absorbed have been compared to experimentally observed values for a set of N = 37 chemically diverse drugs. A sensitivity analysis was performed to assess the influence of various physiological model parameters on the predicted fraction dose absorbed.
resultsA Pearson's correlation coefficient of 0.94 (95% confidence interval: [0.88, 0.97]; p < 0.0001) between the predicted and observed fraction dose absorbed in monkeys was obtained for compounds undergoing non-solubility limited passive absorption (N = 29). The sensitivity analysis revealed that the predictions of fractions dose absorbed in monkeys are very sensitive with respect to inter-individual variations of the small intestinal transit time.
conclusionsThe model is well suited to predict the fraction dose absorbed of passively absorbed compounds after oral administration and to assess the influence of inter-individual physiological variability on oral absorption in monkeys.
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