ArticleInvertebrate neuroscience : IN2007
Characterization of a metabotropic glutamate receptor in the honeybee (Apis mellifera): implications for memory formation.
Article in Invertebrate neuroscience : IN, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Different Paths, Similar Pressures: Divergent Drivers of Genetic Diversity Despite Convergent Genomic Signatures of Selection in Response to Urban Intensity in Two Oligolectic Bee Species.Molecular ecology · 2026Article
- The diversity of insecticide target site mutations in Apis mellifera.BMC genomics · 2026Article
- Divergent sensory transcriptomic profiles in positive and negative learning in Bicyclus Anynana butterflies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility.Genetics · 2023Article
- Nuclear translocation of vitellogenin in the honey bee (Apidologie · 2022Article
- Effect ofBioMed research international · 2020Article
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- Differential protein expression analysis following olfactory learning in Apis cerana.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Article
- Metabotropic Glutamate Receptors: MODULATORS OF CONTEXT-DEPENDENT FEEDING BEHAVIOUR IN C. ELEGANS.The Journal of biological chemistry · 2015Article
- Contrasting Effects of Histone Deacetylase Inhibitors on Reward and Aversive Olfactory Memories in the Honey Bee.Insects · 2014Article
- Ecto- and endoparasite induce similar chemical and brain neurogenomic responses in the honey bee (Apis mellifera).BMC ecology · 2013Article
- Gene expression analysis following olfactory learning in Apis mellifera.Molecular biology reports · 2013Article
- Epigenetic modification of gene expression in honey bees by heterospecific gland secretions.PloS one · 2012Article
- Acute disruption of the NMDA receptor subunit NR1 in the honeybee brain selectively impairs memory formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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4 authors.
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Abstract
G-protein-coupled metabotropic glutamate receptors (GPC mGluRs) are important constituents of glutamatergic synapses where they contribute to synaptic plasticity and development. Here we characterised a member of this family in the honeybee. We show that the honeybee genome encodes a genuine mGluR (AmGluRA) that is expressed at low to medium levels in both pupal and adult brains. Analysis of honeybee protein sequence places it within the type 3 GPCR family, which includes mGlu receptors, GABA-B receptors, calcium-sensing receptors, and pheromone receptors. Phylogenetic comparisons combined with pharmacological evaluation in HEK 293 cells transiently expressing AmGluRA show that the honeybee protein belongs to the group II mGluRs. With respect to learning and memory AmGluRA appears to be required for memory formation. Both agonists and antagonists selective against the group II mGluRs impair long-term (24 h) associative olfactory memory formation when applied 1 h before training, but have no effect when injected post-training or pre-testing. Our results strengthen the notion that glutamate is a key neurotransmitter in memory processes in the honeybee.
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