ArticleGene therapy & molecular biology2006
Isolation of genes controlling apoptosis through their effects on cell survival.
Article in Gene therapy & molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy.Scientific reports · 2022Article
- Long non‑coding RNA GAS5 regulates myocardial ischemia‑reperfusion injury through the PI3K/AKT apoptosis pathway by sponging miR‑532‑5p.International journal of molecular medicine · 2020Article
- Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival.Bioscience reports · 2017Article
- Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.Gut · 2017Article
- C-MYC-induced upregulation of lncRNA SNHG12 regulates cell proliferation, apoptosis and migration in triple-negative breast cancer.American journal of translational research · 2017Article
- Long non-coding RNA SNHG5 suppresses gastric cancer progression by trapping MTA2 in the cytosol.Oncogene · 2016Article
- Review
- Small nucleolar RNAs functioning and potential roles in cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression.Cell reports · 2014Article
- Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma.International journal of clinical and experimental pathology · 2014Article
- Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5.BioMed research international · 2013Article
- Are snoRNAs and snoRNA host genes new players in cancer?Nature reviews. Cancer · 2012Review
- Knockdown of cyclin-dependent kinase inhibitors induces cardiomyocyte re-entry in the cell cycle.The Journal of biological chemistry · 2011Article
- Article
- Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5).Molecular pharmacology · 2010Article
- GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer.Oncogene · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The identification of the most suitable molecular targets for gene and drug therapy is the crucial first step in the development of new disease treatments. The rational identification of such targets depends on a detailed understanding of the pathological changes occuring at the molecular level. We have applied forward genetics approaches to the identification of the critical genes involved in the control of apoptosis in mammalian cells, since defective control of apoptosis underlies many diseases, including cancer and neurodegenerative diseases. We have identified two groups of genes by their effects on cell survival using retroviral cDNA functional expression cloning and retroviral insertional mutagenesis. The identification of these novel genes opens up new areas for apoptosis research and subsequently for the development of new gene and drug therapies.
Identifiers
17372619PMC1828370What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.