ArticleMolecular and cellular biology2007
Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Distinct roles of histone H2B ubiquitination at promoters and coding regions of Pol II-transcribed stress genes.Genome biology · 2025Article
- Kdm1a safeguards the topological boundaries of PRC2-repressed genes and prevents aging-related euchromatinization in neurons.Nature communications · 2024Article
- The Cross-Regulation Between Set1, Clr4, and Lsd1/2 in Schizosaccharomyces pombe.PLoS genetics · 2024Article
- The Fission Yeast Mating-Type Switching Motto: "One-for-Two" and "Two-for-One".Microbiology and molecular biology reviews : MMBR · 2023Review
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- Molecular signature of the imprintosome complex at the mating-type locus in fission yeast.Microbial cell (Graz, Austria) · 2018Article
- Review
- Nucleation and spreading of a heterochromatic domain in fission yeast.Nature communications · 2016Article
- The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.PloS one · 2015Article
- Identification of telomere-associated molecules by engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP).Scientific reports · 2013Article
- Lsd1 and lsd2 control programmed replication fork pauses and imprinting in fission yeast.Cell reports · 2012Article
- Molecular mechanisms and potential functions of histone demethylases.Nature reviews. Molecular cell biology · 2012Review
- Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors.Nature structural & molecular biology · 2010Article
- Article
- Developmental roles of the histone lysine demethylases.Development (Cambridge, England) · 2009Review
- Evolutionary history of histone demethylase families: distinct evolutionary patterns suggest functional divergence.BMC evolutionary biology · 2008Article
- Dynamic transcriptome of Schizosaccharomyces pombe shown by RNA-DNA hybrid mapping.Nature genetics · 2008Article
- siRNA-mediated heterochromatin establishment requires HP1 and is associated with antisense transcription.Molecular cell · 2008Article
- An RNA polymerase III-dependent heterochromatin barrier at fission yeast centromere 1.PloS one · 2007Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
In this study, we characterize a four-protein nucleosome-binding complex from Schizosaccharomyces pombe, termed SAPHIRE, that includes two orthologs of human Lsd1, a histone demethylase. The SAPHIRE complex is essential for cell viability, whereas saphire mutants lacking key conserved catalytic residues are viable but thermosensitive, suggesting that SAPHIRE has both an important enzymatic function and an essential nonenzymatic function. SAPHIRE is present in (or adjacent to) particular heterochromatic loci and also in the transcription start site regions of many highly active polymerase II genes. However, ribosomal protein genes are notably SAPHIRE deficient. SAPHIRE promotes activation, as target genes are selectively attenuated in saphire mutants. Interestingly, saphire mutants display increased histone H3 lysine 4 dimethylation, a modification typically associated with euchromatin. SAPHIRE localization is dynamic, as activated genes rapidly acquire SAPHIRE. Furthermore, saphire mutants dramatically shift a heterochromatin-euchromatin boundary in Chr1, suggesting a novel role in boundary regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.