Broad-spectrum antiviral activity of small interfering RNA targeting the conserved RNA termini of Lassa virus.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

1. Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants.Pharmaceuticals (Basel, Switzerland) · 2025
   Review
2. Emerging Strategies and Progress in the Medical Management of Marburg Virus Disease.Pathogens (Basel, Switzerland) · 2025
   Review
3. Current perspectives on vaccines and therapeutics for Lassa Fever.Virology journal · 2024
   Review
4. Antiviral and protective effect of small interfering RNAs against rift valley fever virus in vitro.Molecular biology reports · 2023
   Article
5. Pathogenicity and virulence mechanisms of Lassa virus and its animal modeling, diagnostic, prophylactic, and therapeutic developments.Virulence · 2021
   Review
6. Diagnostics for Lassa fever virus: a genetically diverse pathogen found in low-resource settings.BMJ global health · 2019
   Article
7. A review on current status of antiviral siRNA.Reviews in medical virology · 2018
   Review
8. Protection against lethal Marburg virus infection mediated by lipid encapsulated small interfering RNA.The Journal of infectious diseases · 2014
   Article
9. Rescue of a recombinant Machupo virus from cloned cDNAs and in vivo characterization in interferon (αβ/γ) receptor double knockout mice.Journal of virology · 2014
   Article
10. Small interfering RNA inhibition of Andes virus replication.PloS one · 2014
    Article
11. Highlights in antiviral drug research: antivirals at the horizon.Medicinal research reviews · 2013
    Review
12. Multifunctional nature of the arenavirus RING finger protein Z.Viruses · 2012
    Review
13. Reverse genetics recovery of Lujo virus and role of virus RNA secondary structures in efficient virus growth.Journal of virology · 2012
    Article
14. Progress in the experimental therapy of severe arenaviral infections.Future microbiology · 2011
    Review
15. Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever.Antiviral research · 2011
    Review
16. Minigenomes, transcription and replication competent virus-like particles and beyond: reverse genetics systems for filoviruses and other negative stranded hemorrhagic fever viruses.Antiviral research · 2011
    Review
17. Evaluation of Lassa antiviral compound ST-193 in a guinea pig model.Antiviral research · 2011
    Article
18. Inhibition of Junín virus replication by small interfering RNAs.Antiviral research · 2009
    Article
19. Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants.PLoS neglected tropical diseases · 2009
    Article
20. Efficient reverse genetics generation of infectious junin viruses differing in glycoprotein processing.Journal of virology · 2009
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as