ArticleGenome biology2007
Sense-antisense pairs in mammals: functional and evolutionary considerations.
Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Exploring the Frontier: Antisense Long Non-Coding RNAs as Key Regulators in Alzheimer's Disease.Aging and disease · 2024Review
- Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing.Cell reports · 2021Article
- Computational analysis of sense-antisense chimeric transcripts reveals their potential regulatory features and the landscape of expression in human cells.NAR genomics and bioinformatics · 2021Article
- Brain Long Noncoding RNAs: Multitask Regulators of Neuronal Differentiation and Function.Molecules (Basel, Switzerland) · 2021Review
- Unveiling the Impact of the Genomic Architecture on the Evolution of Vertebrate microRNAs.Frontiers in genetics · 2017Review
- Article
- A Genome-Wide Landscape of Retrocopies in Primate Genomes.Genome biology and evolution · 2015Article
- Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving theTranslational neuroscience · 2015Review
- Splicing Express: a software suite for alternative splicing analysis using next-generation sequencing data.PeerJ · 2015Article
- Genome-wide determination of poly(A) sites in Medicago truncatula: evolutionary conservation of alternative poly(A) site choice.BMC genomics · 2014Article
- Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease.Frontiers in genetics · 2014Review
- Long non-coding RNAs in haematological malignancies.International journal of molecular sciences · 2013Review
- Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro.BMC genomics · 2013Article
- Testing for natural selection in human exonic splicing regulators associated with evolutionary rate shifts.Journal of molecular evolution · 2013Article
- Gene copy-number polymorphism caused by retrotransposition in humans.PLoS genetics · 2013Article
- Sense-antisense gene pairs: sequence, transcription, and structure are not conserved between human and mouse.Frontiers in genetics · 2013Article
- Cis-acting noncoding RNAs: friends and foes.Nature structural & molecular biology · 2012Review
- SPLOOCE: a new portal for the analysis of human splicing variants.RNA biology · 2012Article
- Article
- Identification of potential antisense transcripts in rice using conventional microarray.Molecular biotechnology · 2012Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA significant number of genes in mammalian genomes are being found to have natural antisense transcripts (NATs). These sense-antisense (S-AS) pairs are believed to be involved in several cellular phenomena.
resultsHere, we generated a catalog of S-AS pairs occurring in the human and mouse genomes by analyzing different sources of expressed sequences available in the public domain plus 122 massively parallel signature sequencing (MPSS) libraries from a variety of human and mouse tissues. Using this dataset of almost 20,000 S-AS pairs in both genomes we investigated, in a computational and experimental way, several putative roles that have been assigned to NATs, including gene expression regulation. Furthermore, these global analyses allowed us to better dissect and propose new roles for NATs. Surprisingly, we found that a significant fraction of NATs are artifacts produced by genomic priming during cDNA library construction.
conclusionWe propose an evolutionary and functional model in which alternative polyadenylation and retroposition account for the origin of a significant number of functional S-AS pairs in mammalian genomes.
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