ArticleBMC infectious diseases2007
Sex- and age-dependent association of SLC11A1 polymorphisms with tuberculosis in Chinese: a case control study.
Article in BMC infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases: systematic review and meta-analysis.Genes and immunity · 2015Pooled it
- SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta-analysis.PloS one · 2011Pooled it
- Sex Differences in TB Clinical Presentation, Drug Exposure, and Treatment Outcomes in India.Chest · 2023Article
- Research progress on genetic control of host susceptibility to tuberculosis.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Review
- Association ofFrontiers in genetics · 2022Article
- Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution?PLoS genetics · 2020Article
- Genomics of human pulmonary tuberculosis: from genes to pathways.Current genetic medicine reports · 2017Article
- Polymorphisms in TICAM2 and IL1B are associated with TB.Genes and immunity · 2015Article
- Inverted expression profiles of sex-biased genes in response to toxicant perturbations and diseases.PloS one · 2013Article
- Innate immune gene polymorphisms in tuberculosis.Infection and immunity · 2012Review
- Tag SNP polymorphism of CCL2 and its role in clinical tuberculosis in Han Chinese pediatric population.PloS one · 2011Article
- Tuberculosis as a complex trait: impact of genetic epidemiological study design.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Genetic epidemiology of tuberculosis susceptibility: impact of study design.PLoS pathogens · 2011Review
- A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.American journal of respiratory and critical care medicine · 2010Article
- Genetic resistance of mice to Mycobacterium paratuberculosis is influenced by Slc11a1 at the early but not at the late stage of infection.Infection and immunity · 2008Article
- Host genetics and tuberculosis: Theory of genetic polymorphism and tuberculosis.Lung India : official organ of Indian Chest SocietyArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHost genetic factors are important determinants in tuberculosis (TB). The SLC11A1 (or NRAMP1) gene has been studied extensively for genetic association with TB, but with inconsistent findings. In addition, no study has yet looked into the effect of sex and age on the relationship between SLC11A1 polymorphisms and TB.
methodsA case-control study was conducted. In total, 278 pulmonary TB patients and 282 sex- and age-matched controls without TB were recruited. All subjects were ethnic Chinese. On the basis of linkage disequilibrium pattern, three genetic markers from SLC11A1 and one from the nearby IL8RB locus were selected and examined for association with TB susceptibility. These markers were genotyped using single strand conformation polymorphism analysis or fragment analysis of amplified products.
resultsStatistically significant differences in allele (P = 0.0165, OR = 1.51) and genotype (P = 0.0163, OR = 1.59) frequencies of the linked markers SLC6a/b (classically called D543N and 3'UTR) of the SLC11A1 locus were found between patients and controls. With stratification by sex, positive associations were identified in the female group for both allele (P = 0.0049, OR = 2.54) and genotype (P = 0.0075, OR = 2.74) frequencies. With stratification by age, positive associations were demonstrated in the young age group (age < or =65 years) for both allele (P = 0.0047, OR = 2.52) and genotype (P = 0.0031, OR = 2.92) frequencies. All positive findings remained significant even after correction for multiple comparisons. No significant differences were noted in either the male group or the older age group. No significant differences were found for the other markers (one SLC11A1 marker and one IL8RB marker) either.
conclusionThis study confirmed the association between SLC11A1 and TB susceptibility and demonstrated for the first time that the association was restricted to females and the young age group.
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