ArticleBiochemical Society transactions2007
Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models.
Article in Biochemical Society transactions, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Polyamines: Functions, Metabolism, and Role in Human Disease Management.Medical sciences (Basel, Switzerland) · 2021Review
- High expression ofWorld journal of gastroenterology · 2019Article
- Article
- Dietary polyamine intake and colorectal cancer risk in postmenopausal women.The American journal of clinical nutrition · 2015Observational
- Effects of a grape-supplemented diet on proliferation and Wnt signaling in the colonic mucosa are greatest for those over age 50 and with high arginine consumption.Nutrition journal · 2015Article
- Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice.Scientific reports · 2014Article
- Gut microbes, diet, and cancer.Cancer treatment and research · 2014Review
- Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine.Cancer discovery · 2013Article
- L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis.PloS one · 2012Article
- Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- Polyamines: total daily intake in adolescents compared to the intake estimated from the Swedish Nutrition Recommendations Objectified (SNO).Food & nutrition research · 2011Article
- Meat consumption, nonsteroidal anti-inflammatory drug use, and mortality among colorectal cancer patients in the California Teachers Study.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Transitions at CpG dinucleotides, geographic clustering of TP53 mutations and food availability patterns in colorectal cancer.PloS one · 2009Article
- Identification and characterization of a diamine exporter in colon epithelial cells.The Journal of biological chemistry · 2008Article
Corrections and comments
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1 author at 1 institution in 1 country.
Funding
Abstract
Colon cancer in humans is influenced by both genetic and dietary risk factors. The majority of colon cancers have somatic mutations in the APC (adenomatous polyposis coli) tumour-suppressor gene. Dietary arginine enhances the risk of APC-dependent colon carcinogenesis in mouse models by a mechanism involving NOS2 (nitric oxide synthase 2), as elimination of NOS2 alleles suppresses this phenotype. DFMO (difluoromethylornithine), a specific inhibitor of polyamine synthesis, also inhibits dietary arginine-induced colon carcinogenesis in C57BL/6J-Apc(Min)/J mice. The primary consequence of dietary arginine is to increase the adenoma grade in these mice. Either loss of NOS2 alleles or inhibition of polyamine synthesis suppresses the arginine-induced increase in adenoma grade. In addition to promoting intestinal carcinogenesis, polyamines can also reduce the efficacy of certain intestinal cancer chemopreventive agents. The NSAID (non-steroidal anti-inflammatory drug) sulindac is a potent inhibitor of intestinal carcinogenesis in the C57BL/6J-Apc(Min)/J mouse model and is used to treat humans with FAP (familial adenomatous polyposis). Dietary putrescine reduces the ability of sulindac to suppress intestinal tumorigenesis in the mouse model. These data suggest that reducing polyamine metabolism and dietary polyamine levels may enhance strategies for colon cancer chemoprevention.
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