ArticleOncogene2007
Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 84 citations in OpenAlex.
- Article
- Cancer research and the mainstream of biology.Frontiers in cell and developmental biology · 2025Review
- Odontoblasts or odontocytes, expression of stem cells markers and differentiation markers among human adult odontoblasts.The Saudi dental journal · 2024Article
- Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development.Biology direct · 2024Review
- Immortalization Reversibility in the Context of Cell Therapy Biosafety.International journal of molecular sciences · 2023Review
- Paradoxical Behavior of Oncogenes Undermines the Somatic Mutation Theory.Biomolecules · 2022Article
- The Role of E3s in Regulating Pluripotency of Embryonic Stem Cells and Induced Pluripotent Stem Cells.International journal of molecular sciences · 2021Review
- Conversion between porcine naïve-like and primed ESCs and specific pluripotency marker identification.In vitro cellular & developmental biology. Animal · 2020Article
- Human Embryonic Stem Cells Acquire Responsiveness to TRAIL upon Exposure to Cisplatin.Stem cells international · 2019Article
- Sphingomyelin synthase 2 overexpression promotes cisplatin-induced apoptosis of HepG2 cells.Oncology letters · 2018Article
- Differential effects of c-myc and ABCB1 silencing on reversing drug resistance in HepG2/Dox cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Reprogramming mediated radio-resistance of 3D-grown cancer cells.Journal of radiation research · 2015Article
- Single-cell gene expression profiles define self-renewing, pluripotent, and lineage primed states of human pluripotent stem cells.Stem cell reports · 2014Article
- Human embryonic and induced pluripotent stem cells express TRAIL receptors and can be sensitized to TRAIL-induced apoptosis.Stem cells and development · 2013Article
- Disruption of prostate epithelial differentiation pathways and prostate cancer development.Frontiers in oncology · 2013Review
- Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels.PloS one · 2013Article
- Striking similarity in the gene expression levels of individual Myc module members among ESCs, EpiSCs, and partial iPSCs.PloS one · 2013Article
- The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells.Genes & development · 2012Article
- Neuronal Differentiation of a Human Induced Pluripotent Stem Cell Line (FS-1) Derived from Newborn Foreskin Fibroblasts.International journal of stem cells · 2012Article
- Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206.Nucleic acids research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryonic stem (ES) cells are self-renewing, pluripotent cell lines, characterized by their potential to differentiate into all cell types. The proto-oncogene product c-Myc has a crucial role in the self-renewal of mouse ES (mES) cells, but its role in human ES (hES) cells is unknown. To investigate c-Myc functions in hES cells, we expressed an inducible c-Myc fused to the hormone-binding domain of the estrogen receptor (c-MycER) protein that is activated by 4-hydroxy-tamoxifen. In contrast to its role in mES cells, activation of c-MycER in hES cells induced apoptosis and differentiation into extraembryonic endoderm and trophectoderm lineages concomitant with reduced expression of the pluripotent markers Oct4 and Nanog. Neither inhibition of caspase activity nor knockdown of p53 by RNA interference impaired the induction of differentiation markers induced by c-Myc activation. In addition, differentiation induced by c-Myc activation was associated with downregulation of alpha6 integrin expression, suggesting an important role for the integrin/extracellular matrix interaction in the regulation of ES cell behavior. None of these effects occurred with deletion of the c-Myc transactivation domain, indicating that c-Myc promotes both apoptosis and differentiation in a transcriptional activity-dependent manner. Together, our results provide new insights into the c-Myc functions regulating hES cell fate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.