Trial reportNeurorehabilitation and neural repair
Locomotor training remodels fMRI sensorimotor cortical activations in children after cerebral hemispherectomy.
Trial report in Neurorehabilitation and neural repair. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Treadmill interventions in children under six years of age at risk of neuromotor delay.The Cochrane database of systematic reviews · 2017Pooled it
- A systematic review of the effectiveness of treadmill training and body weight support in pediatric rehabilitation.Journal of neurologic physical therapy : JNPT · 2009Pooled it
- Predictors and biomarkers of treatment gains in a clinical stroke trial targeting the lower extremity.Stroke · 2014Trial
- Motor Recovery After a Hemispherectomy: Review of Mechanisms and the Potential of Neuromodulation to Enhance Motor Outcomes.Journal of child neurology · 2026Review
- Use of water- and land-based gait training to improve walking capacity in adults with complete spinal cord injury: A pilot study.The journal of spinal cord medicine · 2024Article
- Cortical change after a 2-week novel robotic rehabilitation program in children with prior hemispherectomy: pilot imaging study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Article
- Impacts of Sleep Loss versus Waking Experience on Brain Plasticity: Parallel or Orthogonal?Trends in neurosciences · 2020Review
- Interpreting Intervention Induced Neuroplasticity with fMRI: The Case for Multimodal Imaging Strategies.Neural plasticity · 2016Review
- Gait improvement after treadmill training in ischemic stroke survivors: A critical review of functional MRI studies.Neural regeneration research · 2012Article
- Cerebral hemispherectomy: sensory scores before and after intensive mobility training.Brain & development · 2012Article
- Should body weight-supported treadmill training and robotic-assistive steppers for locomotor training trot back to the starting gate?Neurorehabilitation and neural repair · 2012Article
- Influence of physical exercise on traumatic brain injury deficits: scaffolding effect.Neurotoxicity research · 2012Review
- Adaptive neuroplastic responses in early and late hemispherectomized monkeys.Neural plasticity · 2012Review
- A combined robotic and cognitive training for locomotor rehabilitation: evidences of cerebral functional reorganization in two chronic traumatic brain injured patients.Frontiers in human neuroscience · 2011Article
- Article
- Constraint-induced movement therapy for individuals after cerebral hemispherectomy: a case series.Physical therapy · 2009Article
- Training and exercise to drive poststroke recovery.Nature clinical practice. Neurology · 2008Review
- Fatigue versus activity-dependent fatigability in patients with central or peripheral motor impairments.Neurorehabilitation and neural repairReview
- Electrodermal recording and fMRI to inform sensorimotor recovery in stroke patients.Neurorehabilitation and neural repairArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThis study examined whether locomotor training, which included body weight-supported treadmill therapy, improved walking and induced cortical representational adaptations using functional magnetic resonance imaging in the remaining sensorimotor network after cerebral hemispherectomy.
methodsHemispherectomy patients (n = 12) underwent 2 weeks of gait training for at least 30 hours each. They were tested pre- and posttraining with the Fugl-Meyer Motor Assessment, unassisted single-limb stance time, and usual and fastest walking speeds. Three patients performed voluntary ankle movements as the functional magnetic resonance imaging activation task pre- and posttraining. Control subjects included 5 healthy children tested 2 weeks apart, 2 of whom trained on the treadmill, and 2 hemispherectomy patients who received upper extremity rehabilitation and no gait therapy.
resultsAlthough patients reported improvements with gait training, behavioral outcomes did not significantly change. Training was associated with increased volume and intensity of cortical activation in the primary sensorimotor (S1M1), supplementary motor, motor cingulate, and secondary somatosensory cortex for the paretic foot, along with greater overlap in the representation for each moving foot in S1M1 and the supplementary motor area of the remaining hemisphere. Control subjects showed a decrease in activation in these cortical regions after training.
conclusionsLocomotor training of hemispherectomy patients improved mobility subjectively in association with functional magnetic resonance imaging evidence of cortical remodeling with ankle dorsiflexion. These findings support the notion that hemispherectomy patients may respond to rehabilitation interventions through mechanisms of activity-dependent cortical plasticity. The authors hypothesize that developmentally persistent descending ipsilateral and contralateral corticospinal tracts may allow the remaining hemisphere to maintain bilateral lower extremity motor control after surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.