ArticlePlant physiology2007
Genetic interactions of TGA transcription factors in the regulation of pathogenesis-related genes and disease resistance in Arabidopsis.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 1 of them a synthesis that pooled it.
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Who cites it
154 citing papers in PubMed, 1 synthesis or guideline pooled it, 393 citations in OpenAlex.
- Pearl millet response to drought: A review.Frontiers in plant science · 2023Pooled it
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- A positive feedback loop between NPR1 and SOG1 reinforces genotoxic tolerance in Arabidopsis.Plant communications · 2026Article
- Identification of theBiology · 2026Article
- Expression Profiling and Characterization ofInternational journal of molecular sciences · 2026Article
- The primary nitrate response TGA1 and TGA4 transcription factors are negative regulators of sulfate uptake and metabolism.Plant physiology · 2026Article
- Salicylic acid and the unique TGA transcription factor controls plant immunity against Pseudomonas syringae in Marchantia polymorpha.Plant & cell physiology · 2026Article
- Transcriptome-metabolome integration reveals MYB/WRKY-RGA network and phenylalanine metabolism in potato late blight resistance.BMC plant biology · 2026Article
- Analysis of the TGA gene family and the role of SlTGA03 in tomato resistance to Meloidogyne enterolobii.BMC genomics · 2026Article
- Review
- Cellular energy sensor SnRK1 suppresses salicylic acid-dependent and -independent defenses and bacterial resistance inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transgenic validation of a promoter strongly inducible by Agrobacterium tumefaciens.Scientific reports · 2025Article
- Involvement of Pathogenesis-Related Proteins and Their Roles in Abiotic Stress Responses in Plants.Biomolecules · 2025Review
- A SlMYB78-regulated bifunctional gene cluster for phenolamide and salicylic acid biosynthesis during tomato domestication, reducing disease resistance.Journal of integrative plant biology · 2025Article
- Multi-omics analysis of the regulatory network in winter buds of 'Cabernet Sauvignon' grapevine from dormancy to bud break.Plant biotechnology journal · 2025Article
- The basal level of salicylic acid represses the PRT6 N-degron pathway to modulate root growth and stress response in rice.Plant communications · 2025Article
- Integrated Transcriptome and Metabolome Analysis Elucidates the Defense Mechanisms of Pumpkin Against Gummy Stem Blight.International journal of molecular sciences · 2025Article
- Redox-inactive CC-type glutaredoxins interfere with TGA transcription factor-dependent repression of target promoters in roots.The Plant cell · 2025Article
- A novel mode of WRKY1 regulating PR1-mediated immune balance to defend against powdery mildew in apple.Molecular horticulture · 2025Article
- The transcription factor TGA2 orchestrates salicylic acid signal to regulate cold-induced proline accumulation in Citrus.The Plant cell · 2024Article
94 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TGA transcription factors are implicated as regulators of pathogenesis-related (PR) genes because of their physical interaction with the known positive regulator, nonexpresser of PR gene1 (NPR1). A triple-knockout mutant tga2-1 tga5-1 tga6-1 was shown previously to be defective in the induction of PR genes and systemic acquired resistance, confirming their role in disease resistance. However, the contributions of individual TGA factors have been difficult to discern because of functional redundancy among these factors, as well as possible dual functions for some single factors. In this study, we characterized six TGA factors by reverse genetics. We show that TGA3 is required for both basal and 2,6-dichloroisonicotinic acid-induced transcription of PR genes. The tga3-1 mutants were found to be defective in basal pathogen resistance, whereas induced resistance was unaffected. TGA1 and TGA4 play partially redundant roles in regulation of basal resistance, having only moderate effects on PR gene expression. Additionally, an activation-tagged mutant of TGA6 was able to increase basal as well as induced expression of PR1, demonstrating a positive role for TGA6 on PR gene expression. In contrast, TGA2 has repressor activity on PR gene expression even though it can act as a positive regulator in the tga5-1 tga6-1 null mutant background. Finally, we examined the genetic interaction between tga2-2 and suppressor of npr1 inducible1 (sni1-1). TGA2's repressor activity overlaps with SNI1 because the tga2-2 sni1-1 double mutant shows a synergistic effect on PR gene expression.
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