ArticleBiophysical journal2007
Interaction of alamethicin pores in DMPC bilayers.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Ergosterol depletion by fish AMP analogs likely enhances fungal membrane permeability.Biophysical journal · 2025Article
- Multi-oligomeric states of alamethicin ion channel: Assemblies and conductance.Biophysical journal · 2023Article
- Article
- Chiral twist drives raft formation and organization in membranes composed of rod-like particles.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Alamethicin Supramolecular Organization in Lipid Membranes fromBiophysical journal · 2016Article
- Direct visualization of the alamethicin pore formed in a planar phospholipid matrix.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Peptide model helices in lipid membranes: insertion, positioning, and lipid response on aggregation studied by X-ray scattering.European biophysics journal : EBJ · 2011Article
- Molecular simulation of the effect of cholesterol on lipid-mediated protein-protein interactions.Biophysical journal · 2010Article
- Alamethicin aggregation in lipid membranes.The Journal of membrane biology · 2009Article
- Structure of self-aggregated alamethicin in ePC membranes detected by pulsed electron-electron double resonance and electron spin echo envelope modulation spectroscopies.Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the x-ray scattering signal of highly aligned multilayers of the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine containing pores formed by the antimicrobial peptide alamethicin as a function of the peptide/lipid ratio. We are able to obtain information on the structure factor of the pore fluid, which then yields the interaction potential between pores in the plane of the bilayers. Aside from a hard core with a radius corresponding to the geometric radius of the pore, we find a repulsive lipid-mediated interaction with a range of approximately 30 A and a contact value of 2.4 k(B)T. This result is in qualitative agreement with recent theoretical models.
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Registered trials
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