ArticleGenes & development2007
A novel checkpoint mechanism regulating the G1/S transition.
Article in Genes & development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
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- The nuclear cap-binding complex safeguards stress-resistant protein synthesis and proliferation of stem cells.Science advances · 2026Article
- Nanotoxicity of multifunctional stoichiometric cobalt oxide nanoparticles (SCoONPs) with repercussions toward apoptosis, necrosis, and cancer necrosis factor (TNF-α) at nano-biointerfaces.Toxicology research · 2023Review
- eIF2α phosphorylation and the regulation of translation.Current genetics · 2020Review
- Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress.iScience · 2019Article
- β-N-methylamino-L-alanine (BMAA) suppresses cell cycle progression of non-neuronal cells.Scientific reports · 2018Article
- The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1.G3 (Bethesda, Md.) · 2018Article
- Activation of Gcn2 in response to different stresses.PloS one · 2017Article
- Stress-induced inhibition of translation independently of eIF2α phosphorylation.Journal of cell science · 2015Article
- Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress.PLoS genetics · 2015Article
- Article
- Proline responding1 Plays a Critical Role in Regulating General Protein Synthesis and the Cell Cycle in Maize.The Plant cell · 2014Article
- Crosstalk between the Tor and Gcn2 pathways in response to different stresses.Cell cycle (Georgetown, Tex.) · 2014Article
- Article
- Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells.Cell cycle (Georgetown, Tex.) · 2012Article
- Whole transcriptome analysis of the silicon response of the diatom Thalassiosira pseudonana.BMC genomics · 2012Article
- Induction of a G1-S checkpoint in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Clustering in cell cycle dynamics with general response/signaling feedback.Journal of theoretical biology · 2012Article
- Role of the RNA-binding protein Nrd1 in stress granule formation and its implication in the stress response in fission yeast.PloS one · 2012Article
- Hpz1 modulates the G1-S transition in fission yeast.PloS one · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultraviolet irradiation of fission yeast cells in G1 phase induced a delay in chromatin binding of replication initiation factors and, consistently, a transient delay in S-phase entry. The cell cycle delay was totally dependent on the Gcn2 kinase, a sensor of the nutritional status, and was accompanied by phosphorylation of the translation initiation factor eIF2alpha and by a general depression of translation. However, the G1-specific synthesis of factors required for DNA replication was not reduced by ultraviolet radiation. The cell cycle delay represents a novel checkpoint with a novel mechanism of action that is not activated by ionizing radiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.