ArticleApplied and environmental microbiology2007
Characterization of genetically matched isolates of Campylobacter jejuni reveals that mutations in genes involved in flagellar biosynthesis alter the organism's virulence potential.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
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- Campylobacteriosis and Control Strategies againstJournal of microbiology and biotechnology · 2024Review
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- The bile salt deoxycholate inducesFrontiers in microbiology · 2022Article
- Experimental Evolution ofFrontiers in microbiology · 2020Article
- Stress Response and Virulence Potential Modulating Effect of Peppermint Essential Oil inBioMed research international · 2019Article
- Characterization of Swedish Campylobacter coli clade 2 and clade 3 water isolates.MicrobiologyOpen · 2018Article
- The food-borne pathogen Campylobacter jejuni responds to the bile salt deoxycholate with countermeasures to reactive oxygen species.Scientific reports · 2017Article
- The food-borne pathogen Campylobacter jejuni depends on the AddAB DNA repair system to defend against bile in the intestinal environment.Scientific reports · 2017Article
- Macrolide resistance mechanisms and virulence factors in erythromycin-resistant Campylobacter species isolated from chicken and swine feces and carcasses.The Journal of veterinary medical science · 2017Article
- Antimicrobial and Virulence-Modulating Effects of Clove Essential Oil on the Foodborne Pathogen Campylobacter jejuni.Applied and environmental microbiology · 2016Article
- Analysis of the Campylobacter jejuni genome by SMRT DNA sequencing identifies restriction-modification motifs.PloS one · 2015Article
- Campylobacter jejuni motility is required for infection of the flagellotropic bacteriophage F341.Applied and environmental microbiology · 2014Article
- Rapid identification of novel immunodominant proteins and characterization of a specific linear epitope of Campylobacter jejuni.PloS one · 2013Article
- Multi-omics approaches to deciphering a hypervirulent strain of Campylobacter jejuni.Genome biology and evolution · 2013Article
- Effects of the Campylobacter jejuni CJIE1 prophage homologs on adherence and invasion in culture, patient symptoms, and source of infection.BMC microbiology · 2012Article
- Hyperosmotic stress response of Campylobacter jejuni.Journal of bacteriology · 2012Article
- Interactive effects between diet and genotypes of host and pathogen define the severity of infection.Ecology and evolution · 2012Article
- FdhTU-modulated formate dehydrogenase expression and electron donor availability enhance recovery of Campylobacter jejuni following host cell infection.Journal of bacteriology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenotypic and genotypic evidence suggests that not all Campylobacter jejuni isolates are pathogenic for humans. We hypothesized that differences in gene content or gene expression alter the degree of pathogenicity of C. jejuni isolates. A C. jejuni isolate (Turkey) recovered from a turkey and a second C. jejuni isolate (CS) recovered from a chicken differed in their degrees of in vitro and in vivo virulence. The C. jejuni Turkey isolate invaded INT 407 human epithelial cells and secreted the Cia (Campylobacter invasion antigen) proteins, while the C. jejuni CS isolate was noninvasive for human epithelial cells and did not secrete the Cia proteins. Newborn piglets inoculated with the C. jejuni Turkey isolate developed more severe clinical signs of campylobacteriosis than piglets inoculated with the C. jejuni CS isolate. Additional work revealed that flagellin was not expressed in the C. jejuni CS isolate. Microarray and real-time reverse transcription-PCR analyses revealed that all flagellar class II genes were significantly downregulated in the C. jejuni CS isolate compared to the C. jejuni Turkey isolate. Finally, nucleotide sequencing of the flgR gene revealed the presence of a single residue that was different in the FlgR proteins of the C. jejuni Turkey and CS isolates. Complementation of the C. jejuni CS isolate with a wild-type copy of the flgR gene restored the isolate's motility. Collectively, these findings support the hypothesis that critical differences in gene content or gene expression can alter the pathogenic potential of C. jejuni isolates.
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