ArticleJournal of bacteriology2007
Septum-localized protein required for filament integrity and diazotrophy in the heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed.
- Evolution of multicellularity genes in Cyanobacteria in the lead up to the great oxidation event.Communications biology · 2025Article
- Quantitative assessment of hormogonia induction in Nostoc punctiforme by a fluorescent reporter strain.Journal of experimental botany · 2025Article
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- The periplasmic and cytoplasmic faces of septal protein SepJ from filamentous cyanobacteria.Journal of bacteriology · 2025Review
- Genome Engineering by RNA-Guided Transposition forACS synthetic biology · 2024Article
- The Role of MreB, MreC and MreD in the Morphology of the Diazotrophic Filament ofLife (Basel, Switzerland) · 2022Article
- Varied solutions to multicellularity: The biophysical and evolutionary consequences of diverse intercellular bonds.Biophysics reviews · 2022Review
- Comparative Network Biology Discovers Protein Complexes That Underline Cellular Differentiation in Anabaena sp.Molecular & cellular proteomics : MCP · 2022Article
- Final Destination? PinpointingLife (Basel, Switzerland) · 2021Article
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- Heterocyst Septa Contain Large Nanopores That Are Influenced by the Fra Proteins in the Filamentous CyanobacteriumJournal of bacteriology · 2021Article
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- Coexistence of Communicating and Noncommunicating Cells in the Filamentous CyanobacteriummSphere · 2021Article
- Structural Determinants and Their Role in Cyanobacterial Morphogenesis.Life (Basel, Switzerland) · 2020Review
- The role of the cytoskeletal proteins MreB and FtsZ in multicellular cyanobacteria.FEBS open bio · 2020Article
- Loss of Filamentous Multicellularity inJournal of bacteriology · 2020Article
- The small CaBMC microbiology · 2020Article
- Identification and characterization of novel filament-forming proteins in cyanobacteria.Scientific reports · 2020Article
- Fischerella thermalis: a model organism to study thermophilic diazotrophy, photosynthesis and multicellularity in cyanobacteria.Extremophiles : life under extreme conditions · 2019Review
- Article
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9 authors.
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Abstract
Heterocysts, formed when filamentous cyanobacteria, such as Anabaena sp. strain PCC 7120, are grown in the absence of combined nitrogen, are cells that are specialized in fixing atmospheric nitrogen (N(2)) under oxic conditions and that transfer fixed nitrogen to the vegetative cells of the filament. Anabaena sp. mutants whose sepJ gene (open reading frame alr2338 of the Anabaena sp. genome) was affected showed filament fragmentation and arrested heterocyst differentiation at an early stage. In a sepJ insertional mutant, a layer similar to a heterocyst polysaccharide layer was formed, but the heterocyst-specific glycolipids were not synthesized. The sepJ mutant did not exhibit nitrogenase activity even when assayed under anoxic conditions. In contrast to proheterocysts produced in the wild type, those produced in the sepJ mutant still divided. SepJ is a multidomain protein whose N-terminal region is predicted to be periplasmic and whose C-terminal domain resembles an export permease. Using a green fluorescent protein translationally fused to the carboxyl terminus of SepJ, we observed that in mature heterocysts and vegetative cells, the protein is localized at the intercellular septa, and when cell division starts, it is localized in a ring whose position is similar to that of a Z ring. SepJ is a novel composite protein needed for filament integrity, proper heterocyst development, and diazotrophic growth.
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