ArticleJournal of bacteriology2007
Identification and characterization of genes encoding a putative ABC-type transporter essential for utilization of gamma-hexachlorocyclohexane in Sphingobium japonicum UT26.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 52 citations in OpenAlex.
- Revelation of bioremediation approaches for hexachlorocyclohexane degradation in soil.World journal of microbiology & biotechnology · 2023Review
- Plastic leachates impair picophytoplankton and dramatically reshape the marine microbiome.Microbiome · 2022Article
- Comparative proteomics unravelled the hexachlorocyclohexane (HCH) isomers specific responses in an archetypical HCH degrading bacterium Sphingobium indicum B90A.Environmental science and pollution research international · 2021Article
- Structural mechanism of phospholipids translocation by MlaFEDB complex.Cell research · 2020Article
- Complexity of Complement Resistance Factors Expressed byJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis.Scientific reports · 2017Article
- Comparison of the complete genome sequences of four γ-hexachlorocyclohexane-degrading bacterial strains: insights into the evolution of bacteria able to degrade a recalcitrant man-made pesticide.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- Comparative genomic analysis of nine Sphingobium strains: insights into their evolution and hexachlorocyclohexane (HCH) degradation pathways.BMC genomics · 2014Article
- Proteomic strategy for the analysis of the polychlorobiphenyl-degrading cyanobacterium Anabaena PD-1 exposed to Aroclor 1254.PloS one · 2014Article
- Characterization of a MexAB-OprM efflux system necessary for productive metabolism of Pseudomonas azelaica HBP1 on 2-hydroxybiphenyl.Frontiers in microbiology · 2013Article
- The ABC transporters in Candidatus Liberibacter asiaticus.Proteins · 2012Article
- Comparative metagenomic analysis of soil microbial communities across three hexachlorocyclohexane contamination levels.PloS one · 2012Article
- Complete genome sequence of the representative γ-hexachlorocyclohexane-degrading bacterium Sphingobium japonicum UT26.Journal of bacteriology · 2010Article
- Biochemistry of microbial degradation of hexachlorocyclohexane and prospects for bioremediation.Microbiology and molecular biology reviews : MMBR · 2010Review
- An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sphingobium japonicum UT26 utilizes gamma-hexachlorocyclohexane (gamma-HCH) as its sole source of carbon and energy. In our previous studies, we cloned and characterized genes encoding enzymes for the conversion of gamma-HCH to beta-ketoadipate in UT26. In this study, we analyzed a mutant obtained by transposon mutagenesis and identified and characterized new genes encoding a putative ABC-type transporter essential for the utilization of gamma-HCH in strain UT26. This putative ABC transporter consists of four components, permease, ATPase, periplasmic protein, and lipoprotein, encoded by linK, linL, linM, and linN, respectively. Mutation and complementation analyses indicated that all the linKLMN genes are required, probably as a set, for gamma-HCH utilization in UT26. Furthermore, the mutant cells deficient in this putative ABC transporter showed (i) higher gamma-HCH degradation activity and greater accumulation of the toxic dead-end product 2,5-dichlorophenol (2,5-DCP), (ii) higher sensitivity to 2,5-DCP itself, and (iii) higher permeability of hydrophobic compounds than the wild-type cells. These results strongly suggested that LinKLMN are involved in gamma-HCH utilization by controlling membrane hydrophobicity. This study clearly demonstrated that a cellular factor besides catabolic enzymes and transcriptional regulators is essential for utilization of xenobiotic compounds in bacterial cells.
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