Evidence map›Paper›PMID 17369280›Full record

ArticleArchives of disease in childhood. Fetal and neonatal edition2007

Relationship of tibial speed of sound and lower limb length to nutrient intake in preterm infants.

J Mercy, B Dillon, J Morris, A J Emmerson, M Z Mughal

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of disease in childhood. Fetal and neonatal edition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06199102 (The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants. A Randomized Controlled Study.), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06199102 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants. A Randomized Controlled Study.

TypeinterventionalSponsorPrincess Anna Mazowiecka Hospital, Warsaw, PolandRan2024 to 2027Enrolled130ConditionsVitamin D Deficiency, Osteopenia of Prematurity, Nephrolithiasis, Metabolic Bone DiseaseArmscholecalciferol/ Devikap
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Parenteral amino acid intakes: possible influences of higher intakes on growth and bone status in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2013
    Trial
  6. Trial
  7. Article
  8. Review
  9. A Combined Ultrasonic Backscatter Parameter for Bone Status Evaluation in Neonates.Computational and mathematical methods in medicine · 2020
    Article
  10. Article
  11. Bone status in preterm infant: influences of different nutritional regimens and possible markers of bone disease.Journal of perinatology : official journal of the California Perinatal Association · 2016
    Article
  12. Article
  13. Ultrasound for the assessment of bone quality in preterm and term infants.Journal of perinatology : official journal of the California Perinatal Association · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

J MercyDepartment of Paediatric Medicine, St Mary's Hospital for Women & Children, Hathersage Road, Manchester M13 0JH, England. zulf.mughal@cmmc.nhs.uk
B Dillon
J Morris
A J Emmerson
M Z Mughal
University of Manchester · GBSt Mary's Hospital · GBSt. Mary's Hospital · GBSt. Mary’s Hospital · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetabolic bone disease of prematurity is characterised by impaired postnatal mineralisation of the rapidly growing infant skeleton.

objectiveTo longitudinally evaluate postnatal changes in tibial speed of sound (tSOS; which reflects cortical thickness and bone mineral density) and lower limb length (LLL; a measure of tibial growth) in very low birthweight preterm infants receiving contemporary neonatal care.

methodstSOS and LLL were measured using a quantitative ultrasound device and an electronic neonatal knemometer, respectively, in the same limb, weekly, for a median period of four weeks (3-16 weeks) in 84 preterm infants (median gestation 26.8 weeks (range 23-35.2 weeks) and median birth weight 869.5 g (range 418-1481 g)).

resultsInitial tSOS and LLL were correlated with gestation (r = 0.42, p<0.001; r = 0.76, p<0.001, respectively) and birth weight (r = 0.23, p = 0.038; r = 0.93, p<0.001, respectively). Postnatally, tSOS decreased (r = -0.15, p = 0.011) whereas LLL increased (r = 0.96, p<0.001) with age. The rate of postnatal change in LLL, but not in tSOS, was positively influenced by intake of calcium (p = 0.03), phosphorus (p = 0.01) and vitamin D (p = 0.03).

conclusionsThe postnatal decline in tSOS, which is probably due to cortical thinning secondary to endocortical bone loss, and increase in LLL provide new insight into the development of long bones in preterm infants.

Indexed as

Birth WeightBone DensityCalciumCross-Sectional StudiesFemaleGestational AgeHumansInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightLegLongitudinal StudiesMalePhosphorusTibiaUltrasonicsCalciumPhosphorusVitamin D

Identifiers

PMID17369280
PMCPMC2675363
OpenAlexW2156645868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.