ArticleArchives of disease in childhood2007
Respiratory infections for which general practitioners consider prescribing an antibiotic: a prospective study.
Article in Archives of disease in childhood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Biomarkers as point-of-care tests to guide prescription of antibiotics in people with acute respiratory infections in primary care.The Cochrane database of systematic reviews · 2022Pooled it
- Pooled it
- A systematic review of parent and clinician views and perceptions that influence prescribing decisions in relation to acute childhood infections in primary care.Scandinavian journal of primary health care · 2015Pooled it
- Clinical presentation and microbiological diagnosis in paediatric respiratory tract infection: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Pooled it
- Neuraminidase inhibitors for treatment and prophylaxis of influenza in children: systematic review and meta-analysis of randomised controlled trials.BMJ (Clinical research ed.) · 2009Pooled it
- Assessing Knowledge, Attitudes, and Practices of Adults Aged 21-62 Regarding Antibiotic Use for Treatment of Upper Respiratory Tract Infections in Children: A multi-country Cross-Sectional Study.Journal of preventive medicine and hygiene · 2026Article
- Exploring the Impact of Antibiotics on Fever Recovery Time and Hospital Stays in Children with Viral Infections: Insights from Advanced Data Analysis.Antibiotics (Basel, Switzerland) · 2024Article
- Antibiotic prescription for outpatients with influenza and subsequent hospitalisation: A cohort study using insurance data.Influenza and other respiratory viruses · 2023Article
- Antibiotics for lower respiratory tract infection in children presenting in primary care: ARTIC-PC RCT.Health technology assessment (Winchester, England) · 2023Article
- Use of antibiotics and other treatments in Chinese adults with acute cough: An online survey.Integrative medicine research · 2023Article
- Caregivers' Experiences Regarding Antibiotic Usage in Treating Children's Upper Respiratory Tract Infections in Southern Tanzania.The East African health research journal · 2023Article
- Article
- Differences in service and antibiotics use following symptomatic respiratory tract infections between 2016 and 2021 in rural Anhui, China.Epidemiology and infection · 2022Article
- Patterns of antibiotic use, knowledge, and perceptions among different population categories: A comprehensive study based in Arabic countries.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Factors associated with C-reactive protein testing when prescribing antibiotics in general practice: a register-based study.BMC primary care · 2022Article
- Prescribing antibiotics: the use of diagnostic tests in general practice. A register-based study.Scandinavian journal of primary health care · 2021Article
- Parental Knowledge, Attitude, and Practices on Antibiotic Use for Childhood Upper Respiratory Tract Infections during COVID-19 Pandemic in Greece.Antibiotics (Basel, Switzerland) · 2021Article
- Antibiotic Resistance in Pediatric Infections: Global Emerging Threats, Predicting the Near Future.Antibiotics (Basel, Switzerland) · 2021Review
- Antibiotic Stewardship Program Experience in a Training and Research Hospital.Sisli Etfal Hastanesi tip bulteni · 2021Article
- Prevalence and predictors of antibiotic use among children visiting the Emergency Department in a Tertiary Hospital in Malaysia.European journal of pediatrics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine the viral aetiology of respiratory infections in children presenting to primary care with "more than a simple cold".
designObservational study in 18 Oxfordshire general practices over four winters (2000-01 to 2003-04). PATIENTS: 425 children aged 6 months to 12 years with cough and fever for whom general practitioners considered prescribing an antibiotic.
methodsNasopharyngeal aspirate obtained from 408 (96%) children was subjected to PCR for respiratory viruses. Parents completed an illness diary for the duration of illness.
resultsA viral cause of infection was detected in most (77%) children. Clinical symptoms correctly identified the infecting virus in 45% of cases. The duration of illness was short and the time course was very similar for all infecting viruses. One third of children were prescribed an antibiotic (34%), but this made no difference to the rate of parent-assessed recovery (Kruskal-Wallis, p = 0.67). About one in five children with influenza who did not receive an antibiotic had persistent fever on day 7 compared to no children receiving antibiotics (p = 0.02); this difference remained after adjustment for severity and other factors and was not seen with other viruses.
conclusionsMost children receiving antibiotics for respiratory symptoms in general practice have an identifiable viral illness. In routine clinical practice, neither the specific infecting virus nor the use of antibiotics has a significant effect on the time course of illness. Antibiotics may reduce the duration of fever in children with influenza which could reflect an increased risk of secondary bacterial infection for such children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.