ArticleMicrobial pathogenesis2007
Identification of Klebsiella pneumoniae genes uniquely expressed in a strain virulent using a murine model of bacterial pneumonia.
Article in Microbial pathogenesis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Sedative choice altersInfection and immunity · 2026Article
- An alveolar macrophage-targeted ciprofloxacin polymeric prodrug improves survival in a murine model ofAntimicrobial agents and chemotherapy · 2026Article
- Identification and preclinical efficacy evaluation of two lytic bacteriophages targeting highly virulent and multidrug-resistant Klebsiella pneumoniae.Annals of clinical microbiology and antimicrobials · 2025Article
- A gold nanoparticle conjugated single-legged DNA walker driven by catalytic hairpin assembly biosensor to detect a prokaryotic pathogen.Scientific reports · 2024Article
- Submarine Outfalls of Treated Wastewater Effluents are Sources of Extensively- and Multidrug-Resistant KPC- and OXA-48-ProducingFrontiers in microbiology · 2022Article
- FromMicroorganisms · 2021Review
- A murine model demonstrates capsule-independent adaptive immune protection in survivors ofDisease models & mechanisms · 2020Article
- Pulmonary Surfactant Promotes Virulence Gene Expression and Biofilm Formation in Klebsiella pneumoniae.Infection and immunity · 2018Article
- Colonization, Infection, and the Accessory Genome ofFrontiers in cellular and infection microbiology · 2018Review
- Virulence Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Strains from Patients with Necrotizing Skin and Soft Tissue Infections.Scientific reports · 2017Article
- Klebsiella pneumoniae: Going on the Offense with a Strong Defense.Microbiology and molecular biology reviews : MMBR · 2016Review
- Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia.The Journal of infectious diseases · 2016Article
- Genome Sequence of Klebsiella pneumoniae Respiratory Isolate IA565.Genome announcements · 2014Article
- Evaluation of Gram-negative bacterial infection by a stable and conjugative bioluminescence plasmid in a mouse model.Journal of biomedical science · 2014Article
- Correlation of Klebsiella pneumoniae comparative genetic analyses with virulence profiles in a murine respiratory disease model.PloS one · 2014Article
- Immunity to the conserved influenza nucleoprotein reduces susceptibility to secondary bacterial infections.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Characterization of a novel chaperone/usher fimbrial operon present on KpGI-5, a methionine tRNA gene-associated genomic island in Klebsiella pneumoniae.BMC microbiology · 2012Article
- Structural modeling and biochemical characterization of recombinant KPN_02809, a zinc-dependent metalloprotease from Klebsiella pneumoniae MGH 78578.International journal of molecular sciences · 2012Article
- Comparative effects of carbapenems on bacterial load and host immune response in a Klebsiella pneumoniae murine pneumonia model.Antimicrobial agents and chemotherapy · 2011Article
- Host and microbiota factors that control Klebsiella pneumoniae mucosal colonization in mice.Microbes and infection · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Klebsiella pneumoniae is a gram-negative bacterium of significant clinical importance. This study examines the differential pulmonary host anti-bacterial responses towards two clinical isolates of K. pneumoniae. Intratracheal inoculation with 7 x 10(4)CFU of strain 43816 induced 100% mortality in C57BL/6J mice within 5 days post infection, whereas infection with 5 x 10(5)CFU of strain IA565 resulted in 100% survival. Infection with strain 43816 resulted in significant pulmonary and peripheral blood bacterial burden and induction of the chemokines MIP-2, KC and MCP-1 by 24h post infection. In contrast, IA565-infected mice displayed basal chemokine levels and no detectable bacteria by 24h post inoculation were isolated from lungs or peripheral blood. These data indicate an apparent lack of pathogenicity of strain IA565. Since little is known about Klebsiella-specific virulence genes, we have utilized PCR-based genomic DNA and cDNA suppressive subtractive hybridization and identified nine DNA sequences unique to the pathogenic strain of K. pneumoniae 43816. These sequences were highly homologous to enteric bacterial genes regulating iron uptake, fimbrial-mediated adhesion, energy production and conversion, transcriptional regulation, signal transduction, restriction endonuclease activity, and membrane transport.
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