ArticlePain2007
Revelation of a personal placebo response: its effects on mood, attitudes and future placebo responding.
Article in Pain, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Task-dependent functional connectivity of pain is associated with the magnitude of placebo analgesia in pain-free individuals.European journal of pain (London, England) · 2023Trial
- The impact of pharmaceutical form and simulated side effects in an open-label-placebo RCT for improving psychological distress in highly stressed students.Scientific reports · 2023Trial
- Working with patients' treatment expectations - what we can learn from homeopathy.Frontiers in psychology · 2024Review
- Investigating Knowledge, Attitude, and Beliefs Regarding Placebo Interventions in Clinical Practice: A Comparative Study of Nursing and Medical University Students.Advances in medical education and practice · 2020Article
- "Placebo by Proxy" and "Nocebo by Proxy" in Children: A Review of Parents' Role in Treatment Outcomes.Frontiers in psychiatry · 2020Review
- The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects.Pain research & management · 2018Article
- Placebo disclosure does not result in negative changes in mood or attitudes towards health care or the provider.The Journal of manual & manipulative therapy · 2017Article
- Placebo Use in Pain Management: A Mechanism-Based Educational Intervention Enhances Placebo Treatment Acceptability.The journal of pain · 2016Article
- Placebo analgesia enhances descending pain-related effective connectivity: a dynamic causal modeling study of endogenous pain modulation.The journal of pain · 2015Article
- Conditioned placebo analgesia persists when subjects know they are receiving a placebo.The journal of pain · 2015Article
- Article
- Research on placebo analgesia is relevant to clinical practice.Chiropractic & manual therapies · 2014Article
- The potential benefit of the placebo effect in sham-controlled trials: implications for risk-benefit assessments and informed consent.Journal of medical ethics · 2013Article
- Analgesic placebo treatment perceptions: acceptability, efficacy, and knowledge.The journal of pain · 2012Article
- Participants' experiences of being debriefed to placebo allocation in a clinical trial.Qualitative health research · 2012Article
- Factors affecting placebo acceptability: deception, outcome, and disease severity.The journal of pain · 2011Article
- Placebo response to manual therapy: something out of nothing?The Journal of manual & manipulative therapy · 2011Article
- Dynamic nature of the placebo response.The Journal of orthopaedic and sports physical therapy · 2010Article
- Don't ask, don't tell? Revealing placebo responses to research participants and patients.Pain · 2008Article
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
Abstract
While ethics of placebo use has been debated since discovery of the phenomena, there has yet to be a study that examines the aftereffect of individuals learning of a personal placebo response on their future ability to experience a placebo response. In the first study, eleven participants diagnosed with irritable bowel syndrome in a placebo study were interviewed individually about their personal placebo response. We found no changes in attitudes about the likelihood of using medical and non-medical treatments for pain, likelihood of participating in future studies or likeability and trust of experimenters. In addition, we found no changes in mood except for a slight improvement in frustration. In the second study, 77 undergraduate students from the University of Florida were divided into three conditions: placebo, control and repeated baseline. We used a double placebo design with verbal placebo suggestion and conditioning to induce a placebo response and to examine the effect of providing information about a participant's personal placebo response on their future placebo response. Using a heat thermode, we discovered that there were no differences in future pain responding between participants who were told that they experienced a placebo response versus those who were not. In addition, similar to the first study, we found no detrimental effects of the placebo information variables measured. These studies suggest the placebo response persists even after revelation of a personal placebo response and placebo use does not appear to cause adverse effects on mood and other attitude variables assessed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.