ArticleThe Biochemical journal1992
Glucose induces the translocation and the aggregation of glycogen synthase in rat hepatocytes.
Article in The Biochemical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 46 citations in OpenAlex.
- Regulation of glycogen metabolism in yeast and bacteria.FEMS microbiology reviews · 2010Review
- The subcellular localization of yeast glycogen synthase is dependent upon glycogen content.Canadian journal of microbiology · 2010Article
- Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose.The Biochemical journal · 2004Article
- Intracellular distribution of glycogen synthase and glycogen in primary cultured rat hepatocytes.The Biochemical journal · 2001Article
- Glucose induces the translocation of glycogen synthase to the cell cortex in rat hepatocytes.The Biochemical journal · 1997Article
- Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin.The Biochemical journal · 1993Article
- Role of glucose 6-phosphate in the translocation of glycogen synthase in rat hepatocytes.The Biochemical journal · 1992Article
- Regulation of glycogen synthase activation in isolated hepatocytes.Molecular and cellular biochemistryReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Incubation of rat hepatocytes with glucose results in a decrease in the amount of glycogen synthase activity found in supernatants obtained after centrifugation of cell homogenates at 9200 g. The enzymic activity was quantitatively recovered in the sediments. This effect of translocation was dose- and time-dependent and correlated with the amount of immunoreactive enzyme determined by immunoblotting in both fractions. Hydrolysis by alpha-amylase of glycogen accumulated upon incubation with the sugar did not affect the translocation pattern. Translocation was also observed when cells were incubated with 2-deoxyglucose, which did not result in accumulation of glycogen. Immunocytochemical evidence indicates that glucose induces the aggregation of glycogen synthase molecules into clusters which are recovered in the sediments. These results indicate that glucose, in addition to activating glycogen synthase, may trigger changes in the localization of the enzyme in the cell.
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Registered trials
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