ArticleJournal of molecular biology2007
Hydrophobic cooperativity as a mechanism for amyloid nucleation.
Article in Journal of molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing.Antioxidants (Basel, Switzerland) · 2023Article
- Molecular Modification of Kex2 P1' Site Enhances Expression and Druggability of Fungal Defensin.Antibiotics (Basel, Switzerland) · 2023Article
- Modulating Nanodroplet Formation En Route to Fibrillization of Amyloid Peptides with Designed Flanking Sequences.Biomacromolecules · 2022Article
- A coarse-grained mechanical model for folding and unfolding of tropoelastin with possible mutations.Acta biomaterialia · 2021Article
- A theoretical study of polymorphism in VQIVYK fibrils.Biophysical journal · 2021Article
- Protein Supramolecular Structures: From Self-Assembly to Nanovaccine Design.Nanomaterials (Basel, Switzerland) · 2020Review
- Biomolecular Assemblies: Moving from Observation to Predictive Design.Chemical reviews · 2018Review
- Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity.Molecules (Basel, Switzerland) · 2018Article
- The Levinthal Problem in Amyloid Aggregation: Sampling of a Flat Reaction Space.The journal of physical chemistry. B · 2017Article
- An Atomistic View of Amyloidogenic Self-assembly: Structure and Dynamics of Heterogeneous Conformational States in the Pre-nucleation Phase.Scientific reports · 2016Article
- Critical Nucleus Structure and Aggregation Mechanism of the C-terminal Fragment of Copper-Zinc Superoxide Dismutase Protein.ACS chemical neuroscience · 2016Article
- Clusters of isoleucine, leucine, and valine side chains define cores of stability in high-energy states of globular proteins: Sequence determinants of structure and stability.Protein science : a publication of the Protein Society · 2016Article
- Article
- The Rho Termination Factor of Clostridium botulinum Contains a Prion-Like Domain with a Highly Amyloidogenic Core.Frontiers in microbiology · 2015Article
- Interplay between drying and stability of a TIM barrel protein: a combined simulation-experimental study.Journal of the American Chemical Society · 2013Article
- Computational assembly of polymorphic amyloid fibrils reveals stable aggregates.Biophysical journal · 2013Article
- Dissecting the kinetic process of amyloid fiber formation through asymptotic analysis.The journal of physical chemistry. B · 2012Article
- A lattice-gas model for amyloid fibril aggregation.Europhysics letters · 2011Article
- Toward a molecular theory of early and late events in monomer to amyloid fibril formation.Annual review of physical chemistry · 2011Review
- Association thermodynamics and conformational stability of beta-sheet amyloid beta(17-42) oligomers: effects of E22Q (Dutch) mutation and charge neutralization.Biophysical journal · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The kinetics of amyloid fibril formation are in most cases explained by classical nucleation theory, yet the mechanisms behind nucleation are not well understood. We show using molecular dynamics simulations that the hydrophobic cooperativity in the self-association of the model amyloidogenic peptide STVIYE is sufficient to allow for nucleation-dependent polymerization with a pentamer critical nucleus. The role of electrostatics was also investigated. Novel considerations of the electrostatic solvation energy using the Born-Onsager equation are put forth to rationalize the aggregation of charged peptides and provide new insight into the energetic differences between parallel and antiparallel beta-sheets. Together these results help explain the influence of molecular charge in the class of fibril-forming hexapeptides recently designed by Serrano and collaborators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.