ArticleDevelopmental biology2007
Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 41 citations in OpenAlex.
- Predicted Drosophila Interactome Resource and web tool for functional interpretation of differentially expressed genes.Database : the journal of biological databases and curation · 2020Article
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- Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates.Developmental cell · 2019Review
- Novel Strategies for the Generation of Neuronal Diversity: Lessons From the Fly Visual System.Frontiers in molecular neuroscience · 2019Review
- Spatio-temporal relays control layer identity of direction-selective neuron subtypes in Drosophila.Nature communications · 2018Article
- Review
- Centrosome and spindle assembly checkpoint loss leads to neural apoptosis and reduced brain size.The Journal of cell biology · 2017Article
- Retinal determination genes coordinate neuroepithelial specification and neurogenesis modes in the Drosophila optic lobe.Development (Cambridge, England) · 2016Article
- A region-specific neurogenesis mode requires migratory progenitors in the Drosophila visual system.Nature neuroscience · 2015Article
- Optix defines a neuroepithelial compartment in the optic lobe of the Drosophila brain.Neural development · 2014Article
- Trehalase regulates neuroepithelial stem cell maintenance and differentiation in the Drosophila optic lobe.PloS one · 2014Article
- Evidence for tissue-specific Jak/STAT target genes in Drosophila optic lobe development.Genetics · 2013Article
- CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells.Biology open · 2013Article
- Replication protein a links cell cycle progression and the onset of neurogenesis in Drosophila optic lobe development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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- Article
- Impact of molecular biology studies on the understanding of brain tumors in childhood.Current oncology reports · 2012Article
- Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development.PloS one · 2012Article
- Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye.EMBO reports · 2011Article
- Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II.Developmental biology · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Construction of the brain is one of the most complex developmental challenges. Wnt signals shape all tissues, including the brain, and the tumor suppressor adenomatous polyposis coli (APC) is a key negative regulator of Wnt/Wingless (Wg) signaling. We carried out the first assessment of the role of APC proteins in brain development, simultaneously inactivating both APC1 and APC2 in clones of cells in the Drosophila larval optic lobe. We focused on the medulla, where epithelial neural progenitors shift from symmetric to asymmetric divisions across the lateral-medial axis. Loss of both APCs triggers dramatic defects in optic lobe development. Double mutant cells segregate from wild-type neighbors, while double mutant neurons form tangled axonal knots, suggesting changes in cell adhesion. Strikingly, phenotypes are graded along the anterior-posterior axis. Activation of Wg signaling downstream of APC mimics these phenotypes, a dominant-negative TCF blocks them, and a known Wg target, decapentaplegic, is activated in double mutant clones, strongly suggesting that the phenotypes result from activated Wg signaling. We also explored the roles of classic cadherins in differential adhesion. Finally, we propose a model suggesting that Wg signaling regulates fine scale cell fates along the anterior-posterior axis, in part by creating an adhesion gradient and consider possible alternate explanations for our observations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.