ReviewMethods (San Diego, Calif.)2007
Membrane protein prediction methods.
Review in Methods (San Diego, Calif.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed.
- A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency.The Journal of biological chemistry · 2012Trial
- Resurrecting Full-Length Ancestral Schizorhodopsins and Heliorhodopsins with Structure-Guided, Indel-Aware Sequence Reconstruction.ACS omega · 2026Article
- Protein Sorting Prediction.Methods in molecular biology (Clifton, N.J.) · 2024Article
- An Update on "Reverse Vaccinology": The Pathway from Genomes and Epitope Predictions to Tailored, Recombinant Vaccines.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Easy Synthesis of Complex Biomolecular Assemblies: Wheat Germ Cell-Free Protein Expression in Structural Biology.Frontiers in molecular biosciences · 2021Review
- Evidence to Suggest Bacterial Lipoprotein Diacylglyceryl Transferase (Lgt) is a Weakly Associated Inner Membrane Protein.The Journal of membrane biology · 2019Article
- Comparative Genomics ofFrontiers in microbiology · 2019Article
- Discrimination of Native-like States of Membrane Proteins with Implicit Membrane-based Scoring Functions.Journal of chemical theory and computation · 2017Article
- A novel N-terminal region of the membrane β-hexosyltransferase: its role in secretion of soluble protein by Pichia pastoris.Microbiology (Reading, England) · 2016Article
- CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells.Cancer research · 2014Article
- Article
- Membrane protein native state discrimination by implicit membrane models.Journal of computational chemistry · 2013Article
- A benchmark server using high resolution protein structure data, and benchmark results for membrane helix predictions.BMC bioinformatics · 2013Article
- Coordinating the impact of structural genomics on the human α-helical transmembrane proteome.Nature structural & molecular biology · 2013Article
- Article
- Molecular modeling and ligand docking for solute carrier (SLC) transporters.Current topics in medicinal chemistry · 2013Review
- Structural genomics plucks high-hanging membrane proteins.Current opinion in structural biology · 2012Review
- Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein.The Journal of biological chemistry · 2011Article
- A new in-silico method for determination of helical transmembrane domains based on the PepLook scan: application to IL-2Rβ and IL-2Rγc receptor chains.BMC structural biology · 2011Article
- Mapping the protein-protein interface between a toxin and its cognate antitoxin from the bacterial pathogen Streptococcus pyogenes.Biochemistry · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We survey computational approaches that tackle membrane protein structure and function prediction. While describing the main ideas that have led to the development of the most relevant and novel methods, we also discuss pitfalls, provide practical hints and highlight the challenges that remain. The methods covered include: sequence alignment, motif search, functional residue identification, transmembrane segment and protein topology predictions, homology and ab initio modeling. In general, predictions of functional and structural features of membrane proteins are improving, although progress is hampered by the limited amount of high-resolution experimental information available. While predictions of transmembrane segments and protein topology rank among the most accurate methods in computational biology, more attention and effort will be required in the future to ameliorate database search, homology and ab initio modeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.