ReviewCurrent pain and headache reports2007
The relationship between cytokines and pain/depression: a review and current status.
Review in Current pain and headache reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- C-reactive protein is associated with pain-type somatic symptoms independent of mental health symptoms in adolescents: Evidence from the ALSPAC study.Brain, behavior, & immunity - health · 2025Article
- Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders.Bioelectronic medicine · 2023Review
- Prevalence, Risk Factors, Pathophysiology, Potential Biomarkers and Management of Feline Idiopathic Cystitis: An Update Review.Frontiers in veterinary science · 2022Review
- Does the Interaction between Local and Systemic Inflammation Provide a Link from Psychology and Lifestyle to Tissue Health in Musculoskeletal Conditions?International journal of molecular sciences · 2021Review
- Targeting Cytokines for Morphine Tolerance: A Narrative Review.Current neuropharmacology · 2019Review
- ISSLS PRIZE IN CLINICAL SCIENCE 2018: longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode-the good, the bad, and the ugly.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018Article
- Prior exposure to corticosterone markedly enhances and prolongs the neuroinflammatory response to systemic challenge with LPS.PloS one · 2018Article
- Effects of risk factors for and components of metabolic syndrome on the quality of life of patients with systemic lupus erythematosus: a structural equation modeling approach.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- The Relationship of Older Adults' Physical Pain to Depression and Post-Traumatic Stress Disorder (PTSD): A Review.Journal of geriatric medicine and gerontology · 2015Article
- Chronic low back pain in young korean urban males: the life-time prevalence and its impact on health related quality of life.Journal of Korean Neurosurgical Society · 2014Article
- Evaluation of immune parameters in chronic migraine with medication overuse.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- Psychologic and biologic factors associated with fatigue in patients with persistent radiculopathy.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2013Article
- [Cytokines in psychoneuroendocrine immunological context of nonspecific musculoskeletal pain].Schmerz (Berlin, Germany) · 2012Review
- Expectations of pain and accompanying symptoms during cancer treatment.Current pain and headache reports · 2012Review
- Painful diabetic neuropathy is more than pain alone: examining the role of anxiety and depression as mediators and complicators.Current diabetes reports · 2011Review
- Gender differences among middle-aged Koreans for health-related quality of life related to metabolic syndrome.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2011Article
- Sickness behaviors in response to unusual external events in healthy cats and cats with feline interstitial cystitis.Journal of the American Veterinary Medical Association · 2011Article
- [On the role of cytokines in patients with back pain and fibromyalgia].Schmerz (Berlin, Germany) · 2010Article
- Article
- Stress and IL-1beta contribute to the development of depressive-like behavior following peripheral nerve injury.Molecular psychiatry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokines are small protein molecules secreted in response to immune stimuli. Recent research has outlined important roles for proinflammatory cytokines in the cascade of normal physiologic responses to environmental stresses, encompassing so-called sickness behavior that is thought to be an adaptive response to infection and other illnesses. Cytokines are involved in signaling that activates central nervous system glial cells. This activation is part of a poorly understood interaction between immune challenge or injury and host that can lead to the development or facilitation of persistent mood symptoms or pathologic pain. This article reviews evidence that may enhance our understanding of how pathologic symptoms, such as mood disorders and neuropathic pain, may emerge from proinflammatory cytokine activation. Possible conceptualizations of these illnesses and potential treatment implications are explored.
Indexed as
Identifiers
17367587What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.