ArticleBMC bioinformatics2007
The reactive metabolite target protein database (TPDB)--a web-accessible resource.
Article in BMC bioinformatics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Protein Targets of Acetaminophen Covalent Binding in Rat and Mouse Liver Studied by LC-MS/MS.Frontiers in chemistry · 2021Article
- Alterations in the proteome of the respiratory tract in response to single and multiple exposures to naphthalene.Proteomics · 2015Article
- Analysis of naphthalene adduct binding sites in model proteins by tandem mass spectrometry.Chemico-biological interactions · 2012Article
- Molecular mechanisms underlying chemical liver injury.Expert reviews in molecular medicine · 2012Review
- Characterization of model peptide adducts with reactive metabolites of naphthalene by mass spectrometry.PloS one · 2012Article
- Managing the challenge of chemically reactive metabolites in drug development.Nature reviews. Drug discovery · 2011Review
- Sequence tagging reveals unexpected modifications in toxicoproteomics.Chemical research in toxicology · 2011Article
- Protein thiol oxidation in murine airway epithelial cells in response to naphthalene or diethyl maleate.American journal of respiratory cell and molecular biology · 2010Article
- Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners.BMC chemical biology · 2009Article
- Protein electrophile-binding motifs: lysine-rich proteins are preferential targets of quinones.Drug metabolism and disposition: the biological fate of chemicals · 2009Article
- Filling and mining the reactive metabolite target protein database.Chemico-biological interactions · 2009Review
- Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo.Chemical research in toxicology · 2008Article
- Liquid chromatography-electrospray tandem mass spectrometry investigations of fragmentation pathways of biliary 4,4'-methylenedianiline conjugates produced in rats.Analytical and bioanalytical chemistry · 2008Article
- Protein damage by reactive electrophiles: targets and consequences.Chemical research in toxicology · 2008Review
- The plasma proteome, adductome and idiosyncratic toxicity in toxicoproteomics research.Briefings in functional genomics & proteomics · 2008Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe toxic effects of many simple organic compounds stem from their biotransformation to chemically reactive metabolites which bind covalently to cellular proteins. To understand the mechanisms of cytotoxic responses it may be important to know which proteins become adducted and whether some may be common targets of multiple toxins. The literature of this field is widely scattered but expanding rapidly, suggesting the need for a comprehensive, searchable database of reactive metabolite target proteins. DESCRIPTION: The Reactive Metabolite Target Protein Database (TPDB) is a comprehensive, curated, searchable, documented compilation of publicly available information on the protein targets of reactive metabolites of 18 well-studied chemicals and drugs of known toxicity. TPDB software enables i) string searches for author names and proteins names/synonyms, ii) more complex searches by selecting chemical compound, animal species, target tissue and protein names/synonyms from pull-down menus, and iii) commonality searches over multiple chemicals. Tabulated search results provide information, references and links to other databases.
conclusionThe TPDB is a unique on-line compilation of information on the covalent modification of cellular proteins by reactive metabolites of chemicals and drugs. Its comprehensiveness and searchability should facilitate the elucidation of mechanisms of reactive metabolite toxicity. The database is freely available at http://tpdb.medchem.ku.edu/tpdb.html.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.