Evidence map›Paper›PMID 17367498›Full record

ReviewJournal of cellular and molecular medicine

Autonomously vascularized cellular constructs in tissue engineering: opening a new perspective for biomedical science.

E Polykandriotis, A Arkudas, R E Horch, M Stürzl, U Kneser

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04001842 (Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04001842 narecruitingnot on this map

Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes

TypeinterventionalSponsorUniversity of AlexandriaRan2019 to 2030Enrolled10ConditionsMandibular DeficiencyArmsSurgical reconstruction of the mandible using an axially vascularized bone construct
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. An engineered muscle flap for reconstruction of large soft tissue defects.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  6. Article
  7. Review
  8. Tissue engineering and regenerative medicine -where do we stand?Journal of cellular and molecular medicine · 2012
    Review
  9. Article
  10. Improved vascular organization enhances functional integration of engineered skeletal muscle grafts.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
  11. [Upper and lower eyelid blepharoplasty : development of aesthetic periocular plastic surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2011
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. [The development of plastic surgery: retrospective view of 80 years of "Der Chirurg" (The Surgeon)].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2009
    Article
  18. Article
  19. Translating tissue engineering technology platforms into cancer research.Journal of cellular and molecular medicine · 2009
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

E PolykandriotisDepartment of Plastic and Hand Surgery, University of Erlangen Medical Center, Erlangen, Germany.
A Arkudas
R E Horch
M Stürzl
U Kneser
Friedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In tissue engineering cell cultures play a crucial role besides the matrix materials for the end of substituting lost tissue functions. The cell itself is situated at the cross-roads leading to different orders of scale, from molecule to organism and different levels of function, from biochemistry to macrophysiology. Extensive in vitro investigations have dissected a vast amount of cellular phenomena and the role of a number of bioactive substances has been elucidated in the past. Further, recombinant DNA technologies allow modulation of the expression profiles of virtually all kinds of cells. However, issues of vascularization in vivo limit transferability of these observations and restrict upscaling into clinical applications. Novel in vivo models of vascularization have evolved inspired from reconstructive microsurgical concepts and they encompass axial neovascularization by means of vascular induction. This work represents a brief description of latest developments and potential applications of neovascularization and angiogenesis in tissue engineering.

Indexed as

Neovascularization, PhysiologicScienceAnimalsHumansModels, BiologicalTissue Engineering

Identifiers

PMID17367498
PMCPMC4401217
OpenAlexW1991857146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.