ArticleEnvironmental health perspectives2007
Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Efficient and Fast Removal of Aqueous Tungstate by an Iron-Based LDH Delaminated in L-Asparagine.International journal of environmental research and public health · 2022Article
- Tungsten Accumulation in Hot Spring Sediments Resulting from Preferred Sorption of Aqueous Polytungstates to Goethite.International journal of environmental research and public health · 2021Article
- Precision medicine for rheumatologists: lessons from the pharmacogenomics of azathioprine.Clinical rheumatology · 2021Review
- Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice.The pharmacogenomics journal · 2020Article
- Genotype Analysis ofFrontiers in pharmacology · 2020Article
- Genetic Polymorphisms Associated to Folate Transport as Predictors of Increased Risk for Acute Lymphoblastic Leukemia in Mexican Children.Frontiers in pharmacology · 2016Article
- A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469.Pharmacogenetics and genomics · 2014Article
- Cancer cluster investigations: review of the past and proposals for the future.International journal of environmental research and public health · 2014Review
- Perspectives on the causes of childhood leukemia.Chemico-biological interactions · 2012Review
- Unusual space-time patterning of the Fallon, Nevada leukemia cluster: Evidence of an infectious etiology.Chemico-biological interactions · 2012Article
- Article
- Article
- The mammalian aldehyde oxidase gene family.Human genomics · 2009Article
- Sulfite oxidizing enzymes.Biochimica et biophysica acta · 2007Review
- New germline mutations in the hypervariable minisatellite CEB1 in the parents of children with leukaemia.British journal of cancer · 2007Article
- Investigating childhood leukemia in Churchill County, Nevada.Environmental health perspectives · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveIn a study to identify exposures associated with 15 cases of childhood leukemia, we found levels of tungsten, arsenic, and dichlorodiphenyldichloroethylene in participants to be higher than mean values reported in the National Report on Human Exposure to Environmental Chemicals. Because case and comparison families had similar levels of these contaminants, we conducted genetic studies to identify gene polymorphisms that might have made case children more susceptible than comparison children to effects of the exposures.
designWe compared case with comparison children to determine whether differences existed in the frequency of polymorphic genes, including genes that code for enzymes in the folate and purine pathways. We also included discovery of polymorphic forms of genes that code for enzymes that are inhibited by tungsten: xanthine dehydrogenase, sulfite oxidase (SUOXgene), and aldehyde oxidase.
participantsEleven case children were age- and sex-matched with 42 community comparison children for genetic analyses. Twenty parents of case children also contributed to the analyses.
resultsOne bilalleleic gene locus in SUOX was significantly associated with either case or comparison status, depending on which alleles the child carried (without adjusting for multiple comparisons).
conclusionsAlthough genetic studies did not provide evidence that a common agent or genetic susceptibility factor caused the leukemias, the association between a SUOXgene locus and disease status in the presence of high tungsten and arsenic levels warrants further investigation. RELEVANCE: Although analyses of community clusters of cancer have rarely identified causes, these findings have generated hypotheses to be tested in subsequent studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.