ArticleEnvironmental health perspectives2007
Investigating childhood leukemia in Churchill County, Nevada.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 93 citations in OpenAlex.
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- Tungsten toxicity and carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023Article
- Inhalation of Tungsten Metal Particulates Alters the Lung and Bone Microenvironments Following Acute Exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Design and Rationale of the Biomarker Center of the Household Air Pollution Intervention Network (HAPIN) Trial.Environmental health perspectives · 2020Article
- Structural Evidence of Programmed Cell Death Induction by Tungsten in Root Tip Cells ofPlants (Basel, Switzerland) · 2019Article
- Tungsten: an Emerging Toxicant, Alone or in Combination.Current environmental health reports · 2016Review
- Immunotoxic effects of sodium tungstate dihydrate on female B6C3F1/N mice when administered in drinking water.Journal of immunotoxicology · 2016Article
- Tungsten Promotes Sex-Specific Adipogenesis in the Bone by Altering Differentiation of Bone Marrow-Resident Mesenchymal Stromal Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- An update to the toxicological profile for water-soluble and sparingly soluble tungsten substances.Critical reviews in toxicology · 2015Review
- Tungsten targets the tumor microenvironment to enhance breast cancer metastasis.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Increased childhood mortality and arsenic in drinking water in Matlab, Bangladesh: a population-based cohort study.PloS one · 2013Article
- Occurrence of ²¹⁰Po and biological effects of low-level exposure: the need for research.Environmental health perspectives · 2012Review
- Unusual space-time patterning of the Fallon, Nevada leukemia cluster: Evidence of an infectious etiology.Chemico-biological interactions · 2012Article
- Perspectives on the causes of childhood leukemia.Chemico-biological interactions · 2012Review
- Comparison of size and geography of airborne tungsten particles in Fallon, Nevada, and Sweet Home, Oregon, with implications for public health.Journal of environmental and public health · 2012Article
- Article
- Investigation of mechanism(s) of DNA damage induced by 4-monochlorobiphenyl (PCB3) metabolites.Environment international · 2010Article
- Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003-2004.Journal of exposure science & environmental epidemiology · 2009Article
- Tungsten and cobalt in Fallon, Nevada: association with childhood leukemia.Environmental health perspectives · 2008Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSixteen children diagnosed with acute leukemia between 1997 and 2002 lived in Churchill County, Nevada, at the time of or before their illness. Considering the county population and statewide cancer rate, fewer than two cases would be expected.
objectivesIn March 2001, the Centers for Disease Control and Prevention led federal, state, and local agencies in a cross-sectional, case-comparison study to determine if ongoing environmental exposures posed a health risk to residents and to compare levels of contaminants in environmental and biologic samples collected from participating families.
methodsSurveys with more than 500 variables were administered to 205 people in 69 families. Blood, urine, and cheek cell samples were collected and analyzed for 139 chemicals, eight viral markers, and several genetic polymorphisms. Air, water, soil, and dust samples were collected from almost 80 homes to measure more than 200 chemicals.
resultsThe scope of this cancer cluster investigation exceeded any previous study of pediatric leukemia. Nonetheless, no exposure consistent with leukemia risk was identified. Overall, tungsten and arsenic levels in urine and water samples were significantly higher than national comparison values; however, levels were similar among case and comparison groups.
conclusionsAlthough the cases in this cancer cluster may in fact have a common etiology, their small number and the length of time between diagnosis and our exposure assessment lessen the ability to find an association between leukemia and environmental exposures. Given the limitations of individual cancer cluster investigations, it may prove more efficient to pool laboratory and questionnaire data from similar leukemia clusters.
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