ReviewEnvironmental health perspectives2007
Infectious etiologies of childhood leukemia: plausibility and challenges to proof.
Review in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Effectiveness of ertapenem for treatment of infections in children: An evidence mapping and meta-analysis.Frontiers in pediatrics · 2022Pooled it
- Maternal Infection in Pregnancy and Childhood Leukemia: A Systematic Review and Meta-analysis.The Journal of pediatrics · 2020Pooled it
- A meta-analysis of the association between day-care attendance and childhood acute lymphoblastic leukaemia.International journal of epidemiology · 2010Pooled it
- High Childhood Leukemia Mortality Rates in Mexico Associated to Water Contamination in Areas of Oil and Gas Extraction.GeoHealth · 2026Article
- Leukemic fusion genes repress viral gene expression and expel adenovirus from persistently infected human B lymphocytes but evidence of the virus lingers behind.bioRxiv : the preprint server for biology · 2025Article
- No evidence on infectious DNA-based agents in pediatric acute lymphoblastic leukemia using whole metagenome shotgun sequencing.Frontiers in cellular and infection microbiology · 2024Article
- Cesarean Section and Risk of Childhood Acute Lymphoblastic Leukemia in a Population-Based, Record-Linkage Study in California.American journal of epidemiology · 2017Article
- Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children.Cancer causes & control : CCC · 2015Article
- Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia.Epigenetics · 2015Article
- Neonatal infection with species C adenoviruses confirmed in viable cord blood lymphocytes.PloS one · 2015Article
- Daycaritis.Clinical pediatric emergency medicine · 2013Article
- Article
- Spectrum of HLA associations: the case of medically refractory pediatric acute lymphoblastic leukemia.Immunogenetics · 2012Article
- Early life exposure to infections and risk of childhood acute lymphoblastic leukemia.International journal of cancer · 2011Article
- Cancer incidence in the vicinity of Finnish nuclear power plants: an emphasis on childhood leukemia.Cancer causes & control : CCC · 2010Article
- Breastfeeding and early infection in the aetiology of childhood leukaemia in Down syndrome.British journal of cancer · 2009Article
- Strong association of the HLA-DP6 supertype with childhood leukaemia is due to a single allele, DPB1*0601.Leukemia · 2009Article
- Risk factors for childhood leukaemia. Discussion and summary.Radiation protection dosimetry · 2008Article
- Exposure to infections through day-care attendance and risk of childhood leukaemia.Radiation protection dosimetry · 2008Article
- Monthly variation in diagnosis of acute lymphoblastic leukemia and survival outcome in children and adults: 15-year trends at a single center.Hematology, transfusion and cell therapyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infections as well as environmental exposures are proposed determinants of childhood acute lymphoblastic leukemia (ALL), particularly common precursor B-cell ALL (cALL). Lines of investigation test hypotheses that cALL is a rarer result of common infection, that it results from uncommon infection, or that it ensues from abnormal immune development; perhaps it requires a preceding prenatal or early childhood insult. Ideally, studies should document that particular infections precede leukemiA and induce malignant transformation. However, limited detection studies have not directly linked specific human or nonhuman infectious agents with ALL or cALL. Primarily based on surrogate markers of infectious exposure, indirect evidence from ecologic and epidemiologic studies varies widely, but some suggest that infancy or early childhood infectious exposures might protect against childhood ALL or cALL. Several others suggest that maternal infection during pregnancy might increase risk or that certain breast-feeding practices decrease risk. To date, evidence cannot confirm or refute whether at least one infection induces or is a major co-factor for developing ALL or cALL, or perhaps actually protects against disease. Differences in methodology and populations studied may explain some inconsistencies. Other challenges to proof include the likely time lag between infection and diagnosis, the ubiquity of many infections, the influence of age at infection, and the limitations in laboratory assays; small numbers of cases, inaccurate background leukemia rates, and difficulty tracking mobile populations further affect duster investigations. Nevertheless, existing evidence partially supports plausibility and warrants further investigation into potential infectious determinants of ALL and cALL, particularly in the context of multifactorial or complex systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.