ArticleEnvironmental health perspectives2007
New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?Nanomaterials (Basel, Switzerland) · 2022Review
- Review
- Modulation ofChemical research in toxicology · 2020Article
- Genetic ecotoxicology of asbestos pollution in the house mouse Mus musculus domesticus.Environmental science and pollution research international · 2011Article
- The fate of chrysotile-induced multipolar mitosis and aneuploid population in cultured lung cancer cells.PloS one · 2011Article
- Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases.Journal of toxicology and environmental health. Part B, Critical reviews · 2011Review
- Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats: in vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells.Particle and fibre toxicology · 2009Article
- Chrysotile effects on human lung cell carcinoma in culture: 3-D reconstruction and DNA quantification by image analysis.BMC cancer · 2008Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundGenotoxicity is often a prerequisite to the development of malignancy. Considerable evidence has shown that exposure to asbestos fibers results in the generation of chromosomal aberrations and multilocus mutations using various in vitro approaches. However, there is less evidence to demonstrate the contribution of deletions to the mutagenicity of asbestos fibers in vivo.
objectivesIn the present study, we investigated the mutant fractions and the patterns induced by chrysotile fibers in gpt delta transgenic mouse primary embryo fibroblasts (MEFs) and compared the results obtained with hydrogen peroxide (H2O2) in an attempt to illustrate the role of oxyradicals in fiber mutagenesis.
resultsChrysotile fibers induced a dose-dependent increase in mutation yield at the redBA/gam loci in transgenic MEF cells. The number of lambda mutants losing both redBA and gam loci induced by chrysotiles at a dose of 1 microg/cm(2) increased by > 5-fold relative to nontreated controls (p < 0.005). Mutation spectra analyses showed that the ratio of lambda mutants losing the redBA/gam region induced by chrysotiles was similar to those induced by equitoxic doses of H2O2. Moreover, treatment with catalase abrogated the accumulation of y-H2AX, a biomarker of DNA double-strand breaks, induced by chrysotile fibers.
conclusionsOur results provide novel information on the frequencies and types of mutations induced by asbestos fibers in the gpt delta transgenic mouse mutagenic assay, which shows great promise for evaluating fiber/particle mutagenicity in vivo.
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