ArticleThe Journal of comparative neurology2007
Odorants with multiple oxygen-containing functional groups and other odorants with high water solubility preferentially activate posterior olfactory bulb glomeruli.
Article in The Journal of comparative neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Rodent responses to volatile compounds provide insights into the function of floral scent in mammal-pollinated plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb.NeuroImage · 2018Article
- Sedative effects of inhaled essential oil components of traditional fragrance Pogostemon cablin leaves and their structure-activity relationships.Journal of traditional and complementary medicine · 2016Article
- Tuning to odor solubility and sorption pattern in olfactory epithelial responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The sedative effect of inhaled terpinolene in mice and its structure-activity relationships.Journal of natural medicines · 2013Article
- Cluster analysis of rat olfactory bulb responses to diverse odorants.Chemical senses · 2012Article
- Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats.The American journal of pathology · 2012Article
- Photoperiod mediated changes in olfactory bulb neurogenesis and olfactory behavior in male white-footed mice (Peromyscus leucopus).PloS one · 2012Article
- Article
- Mammal pollinators lured by the scent of a parasitic plant.Proceedings. Biological sciences · 2011Article
- The location of olfactory receptors within olfactory epithelium is independent of odorant volatility and solubility.BMC research notes · 2011Article
- Olfactory sensitivity for sperm-attractant aromatic aldehydes: a comparative study in human subjects and spider monkeys.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2011Article
- Statistical analysis of coding for molecular properties in the olfactory bulb.Frontiers in systems neuroscience · 2011Article
- Glomerular activity patterns evoked by natural odor objects in the rat olfactory bulb are related to patterns evoked by major odorant components.The Journal of comparative neurology · 2010Article
- Spatial representations of odorants in olfactory bulbs of rats and mice: similarities and differences in chemotopic organization.The Journal of comparative neurology · 2009Article
- Neural computations with mammalian infochemicals.Journal of chemical ecology · 2008Review
- Chemotopic odorant coding in a mammalian olfactory system.The Journal of comparative neurology · 2007Review
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3 authors at 1 institution in 1 country.
Funding
Abstract
In past studies in which we mapped 2-deoxyglucose uptake evoked by systematically different odorant chemicals across the entire rat olfactory bulb, glomerular responses could be related to each odorant's particular oxygen-containing functional group. In the present study we tested whether aliphatic odorants containing two such functional groups (esters, ketones, acids, alcohols, and ethers) would stimulate the combination of glomerular regions that are associated with each of the functional groups separately, or whether they would evoke unique responses in different regions of the bulb. We found that these very highly water-soluble molecules rarely evoked activity in the regions responding to the individual functional groups; instead, they activated posterior glomeruli located about halfway between the dorsal and ventral extremes in both the lateral and the medial aspects of the bulb. Additional highly water-soluble odorants, including very small molecules with single oxygenic groups, also strongly stimulated these posterior regions, resulting in a statistically significant correlation between posterior 2-deoxyglucose uptake and molecular properties associated with water solubility. By showing that highly water-soluble odorants stimulate a part of the bulb associated with peripheral and ventral regions of the epithelium, our results challenge a prevalent notion that such odorants would activate class I odorant receptors located in zone 1 of the olfactory epithelium, which projects to the dorsal aspect of the bulb.
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