Evidence map›Paper›PMID 17364629›Full record

Trial reportClinical toxicology (Philadelphia, Pa.)2007

Compliance for single and multiple dose regimens of superactivated charcoal: a prospective study of patients in a clinical trial.

Fahim Mohamed, M Roshini Sooriyarachchi, Lalith Senarathna, Shifa Azhar, M H Rezvi Sheriff, Nick A Buckley, Michael Eddleston

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical toxicology (Philadelphia, Pa.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Effect of Taste Additives on the Palatability of Activated Charcoal: a Systematic Review.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023
    Pooled it
  2. First aid interventions by laypeople for acute oral poisoning.The Cochrane database of systematic reviews · 2018
    Pooled it
  3. Trial
  4. Review
  5. Activated charcoal for acute overdose: a reappraisal.British journal of clinical pharmacology · 2016
    Review
  6. Gastrointestinal decontamination in the acutely poisoned patient.International journal of emergency medicine · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Fahim MohamedSouth Asian Clinical Toxicology Research Collaboration, Department of Clinical Medicine, University of Colombo, Sri Lanka.
M Roshini Sooriyarachchi
Lalith Senarathna
Shifa Azhar
M H Rezvi Sheriff
Nick A Buckley
Michael Eddleston
University of Colombo · LKSouth Asian Clinical Toxicology Research Collaboration · LKNorth Central College · US

Funding

Wellcome Trust 063560Wellcome Trust GR063560MAWellcome Trust GR071669MA
6 · The paper itself

Abstract

backgroundAlthough activated charcoal is widely used for the treatment of self-poisoning, its effectiveness is unknown. An important consideration is patient compliance since poor compliance will limit effectiveness. We aimed to describe compliance in a randomized controlled trial (RCT) performed in Sri Lanka, presuming that this would set the upper limits for compliance in routine clinical use.

method1,103 patients randomized to single or multiple (six doses q4h) 50 g doses of superactivated charcoal were prospectively observed. Charcoal was given by study doctors who recorded the amount ingested and the amount of persuasion required for the patients to drink the charcoal.

results559 patients were randomized to receive one dose and 544 to receive six doses. Data was available for 1,071 (97%) patients. Eighty-eight were unable to complete their course; 98 required a NG tube, leaving 885 patients that received the first dose by mouth. The mean estimated amount of the prescribed dose of charcoal taken orally as a single or first dose was 83% (95% C.I. 82-84%). For patients receiving multiple doses, this amount fell over the next five doses to 66% (63-69%). While only 3.2% of patients refused the first dose, 12.3% refused the sixth. Relatively less persuasion was required for patients ingesting the first or single dose; 38% of patients required intense persuasion by the sixth dose.

conclusionCompliance for a single dose of superactivated charcoal among trial patients was good. However, even in the ideal circumstances of a RCT, compliance decreased thereafter for patients taking more than one dose.

Indexed as

Patient ComplianceCharcoalDose-Response Relationship, DrugDrug Administration ScheduleHumansIntubation, GastrointestinalPoisoningProspective StudiesSri LankaCharcoal

Identifiers

PMID17364629
PMCPMC1950600
OpenAlexW2169456510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.