ArticleMycopathologia2007
Prostaglandin E(2) production by high and low virulent strains of Paracoccidioides brasiliensis.
Article in Mycopathologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Article
- Eicosanoid production byVirulence · 2019Review
- Co-opting oxylipin signals in microbial disease.Cellular microbiology · 2019Review
- Candida parapsilosis: from Genes to the Bedside.Clinical microbiology reviews · 2019Review
- 43 kDa Glycoprotein (gp43) fromJournal of immunology research · 2019Article
- Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity.Journal of microbiology (Seoul, Korea) · 2016Review
- Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis.Mediators of inflammation · 2015Article
- Arachidonic acid metabolites in pathogenic yeasts.Lipids in health and disease · 2012Review
- Antifungal activity of some cyclooxygenase inhibitors on Candida albicans: PGE2-dependent mechanism.Folia microbiologica · 2011Article
- Paracoccidioides brasiliensis uses endogenous and exogenous arachidonic acid for PGE x production.Mycopathologia · 2010Article
- Lipid signaling in pathogenic fungi.Annual review of microbiology · 2009Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The production of prostaglandins (PGs) during fungal infections could be an important suppressor factor of host immune response. Host cells are one source of prostaglandin E(2) (PGE(2)); however another potential source of PGE(2) is the fungal pathogen itself. Thus, both host and fungal PGE2 production is theorized to play a role in pathogenesis, being critical for growth of the fungus and to modulate the host immune response. The purpose of this work was to investigate if high and low virulent strains of Paracoccidioides brasiliensis have the capacity to produce PGE(2) in vitro, and if this production was related to the fungal growth. The results demonstrated that both strains of P. brasiliensis produce high levels of PGE(2) and the treatment with indomethacin, a cyclooxygenase inhibitor, significantly reduced the production of this mediator, as well as the viability of the fungus. Thus, our data indicate that PGE(2) is produced by P. brasiliensis by a cyclooxygenase-dependent metabolic pathway, and its production is required for fungal survival. This discovery reveals an important factor that has potentially great implications for understanding the mechanisms of immune deviation during infection.
Indexed as
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Registered trials
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